Evolution of Solid Processing Methods in Continuous Flow Technology: Reactive Extrusion.

Chimia (Aarau)

Department of Pharmaceutical and Biological Chemistry, UCL, School of Pharmacy, 29-39 Brunswick Square, Bloomsbury, London, WC1N 1AX.

Published: May 2023

AI Article Synopsis

  • - The text discusses common problems in continuous flow reactors, such as precipitation, fouling, and blockages that researchers often face.
  • - It emphasizes innovative solutions that have been developed to address these challenges.
  • - The review introduces mechanochemistry and reactive extrusion as promising continuous processes that can effectively handle solid and liquid materials for chemical transformations.

Article Abstract

The frustrations of precipitation, fouling and blockages of liquid-based flow reactors is familiar to all researchers that have worked with continuous flow equipment. There have been many innovative solutions to try and circumvent this issue. This short review will highlight the emerging technique of mechanochemistry and reactive extrusion as a continuous process that can directly work on solid (and liquid) materials and elicit chemical transformations.

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Source
http://dx.doi.org/10.2533/chimia.2023.339DOI Listing

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