AI Article Synopsis
- Solitary fibrous tumor (SFT) of the central nervous system is a rare tumor that can recur and spread to other parts of the body.
- Treatment options for its metastatic form are limited.
- The case report highlights successful treatment with Lu177-FAPI-targeted radionuclide therapy after detecting high levels of fibroblast activating protein (FAP) in the metastatic sites, resulting in a significant clinical response.
Article Abstract
Solitary fibrous tumor (SFT) of the central nervous system (previously called hemangiopericytoma) is a rare mesenchymal tumor. Malignant SFT has a tendency to recur after surgery and can metastasize to distant organs. Treatment options for metastatic disease are limited. This case demonstrated high expression of FAP (fibroblast activating protein) in all metastatic sites with Ga-FAPI positron emission tomography-computed tomography imaging. Subsequently, the patient was treated with Lu177-FAPI-targeted radionuclide therapy. There was significant clinical response. There was mild partial morphological response seen on follow-up imaging.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693355 | PMC |
| http://dx.doi.org/10.4103/ijnm.ijnm_22_23 | DOI Listing |
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