Neuroendocrine breast carcinoma (NEBC) is an uncommon and malignant breast lesion. The absence of proper testing for this type of breast cancer carcinoma exacerbates this paucity. Additionally, only scant evidence of these tumors is present because of the repeated revisions in their diagnostic criteria throughout time. This case report highlights the importance of the correlation between histological and radiological findings in the diagnosis and treatment of neuroendocrine breast cancer. We describe the clinical, radiological, and histological characteristics of a patient diagnosed with neuroendocrine carcinoma. The breast parenchyma was penetrated by a carcinomatous tumor growth that contained trabeculae and lobules, exhibiting mild cytonuclear atypia, and having a low mitotic index. This report emphasizes the value of a multidisciplinary strategy for precise diagnosis and treatment planning.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692488 | PMC |
http://dx.doi.org/10.1016/j.radcr.2023.10.047 | DOI Listing |
Chromosomal instability (CIN) is common in solid tumours and fuels evolutionary adaptation and poor prognosis by increasing intratumour heterogeneity. Systematic characterization of driver events in the TRACERx non-small-cell lung cancer (NSCLC) cohort identified that genetic alterations in six genes, including FAT1, result in homologous recombination (HR) repair deficiencies and CIN. Using orthogonal genetic and experimental approaches, we demonstrate that FAT1 alterations are positively selected before genome doubling and associated with HR deficiency.
View Article and Find Full Text PDFCancer Cell Int
December 2024
Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian, 116023, China.
Background: Neuroendocrine tumors primarily consist of endocrine cells commonly located in neural tissue and the endocrine system. Primary neuroendocrine neoplasms of the breast are highly heterogeneous tumors characterized by a diverse cell population. Their rarity in the breast poses considerable challenges in studying their pathogenesis and developing effective treatments.
View Article and Find Full Text PDFFront Pharmacol
December 2024
Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Cancer Treat Res Commun
December 2024
Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:
Background: The World Health Organization's fifth edition of tumor series classification was published in 2019 and adopted the term 'Neuroendocrine neoplasm (NEN)' to encompass all tumor classes with predominant neuroendocrine differentiation (NED). Based on the updated classification of the NEN, we conducted a case series using the Clinical Data Warehouse platform of SMC.
Methods: In this retrospective study, breast NENs and invasive breast carcinomas no special type (IBCNST) with NED, were defined as 'NENS'.
J Int Med Res
December 2024
Department of Oncology Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with the poorest prognosis among all types of lung cancer. Developing an effective comprehensive strategy remains a key focus. We herein present the first documented case of a 68-year-old man with limited-stage SCLC who has maintained a complete response (CR) for over 30 months to date.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!