AI Article Synopsis
- Rheumatic heart disease (RHD) is a significant global health issue, often resulting from infections with group A streptococcus (GAS) in genetically susceptible individuals.
- *Preventive measures focus on community efforts to stop GAS infections, effective treatment for existing infections, and secondary prophylaxis using intramuscular penicillin.
- *While surgery availability and techniques are improving in areas where RHD is common, innovations in biomaterials and delivery technologies hold promise for better solutions, though high costs pose a challenge.*
Article Abstract
Despite recent public policy initiatives, rheumatic heart disease (RHD) remains a major source of morbidity worldwide. Rheumatic heart disease occurs as a sequela of (group A streptococcal [GAS]) infection in patients with genetic susceptibility. Strategies for prevention of RHD or progression of RHD include prevention of GAS infection with community initiatives, effective treatment of GAS infection, and secondary prophylaxis with intramuscular penicillin. The cardiac surgical community has attempted to improve the availability of surgery in RHD-endemic areas with some success, and operative techniques and outcomes of valve repair continue to improve, potentially offering patients a safer, more durable operation. Innovation offers hope for a more scalable solution with improved biomaterials and transcatheter delivery technology; however, cost remains a barrier.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692356 | PMC |
| http://dx.doi.org/10.1016/j.shj.2023.100219 | DOI Listing |
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