Cu-In Dual Sites with Sulfur Defects toward Superior Ethanol Electrosynthesis from CO Electrolysis.

The electrosynthesis of multi-carbon chemicals from excess carbon dioxide (CO) is an area of great interest for research and commercial applications. However, improving both the yield of CO-to-ethanol conversion and the stability of the catalyst at the same time is proving to be a challenging issue. Here it is proposed to stabilize active Cu(I) and In dual sites with sulfur defects through an electro-driven intercalation strategy, which leads to the delocalization of electron density that enhances orbital hybridizations between the Cu-C and In-H bonds. Hence, the energy barrier for the rate-limiting *CHO formation step is reduced toward the key *OCHCHO* formation during ethanol production, which is also facilitated by the combined Cu site enabling C-C coupling and In site with a higher oxygen affinity based on both thermodynamic and kinetic calculations. Accordingly, such dual-site catalyst achieves a high partial current density toward ethanol of 409 ± 15 mA cm⁻ for over 120 h. Furthermore, a scaled-up flow cell is assembled with an industrial-relevant current of 5.7 A for over 36 h, in which the carbon loss is less than 2.5% and single-pass carbon efficiency is ≈19%.