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Tissue-specific antioxidative response and metabolism of paralytic shellfish toxins in scallop (Chlamys farreri) mantle with Alexandrium dinoflagellate exposure. | LitMetric

Tissue-specific antioxidative response and metabolism of paralytic shellfish toxins in scallop (Chlamys farreri) mantle with Alexandrium dinoflagellate exposure.

Mar Pollut Bull

Key Laboratory of Marine Genetics and Breeding (Ocean University of China), Ministry of Education, 5 Yushan Road, Qingdao 266003, China; Laboratory for Marine Fisheries Science and Food Production Processes, National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Qingdao 266237, China. Electronic address:

Published: January 2024

AI Article Synopsis

  • Bivalves, like Zhikong scallops, can adapt to harmful paralytic shellfish toxins (PSTs) from dinoflagellates, which impact fisheries and public health.
  • A study revealed that exposure to the PST-producing dinoflagellate Alexandrium minutum caused increased accumulation of toxins and specific gene responses related to oxidation and reduction in the scallop mantle over 15 days.
  • Gene analysis highlighted 16 responsive modules linked to toxin concentration, suggesting potential biomarkers and mechanisms for maintaining neurotransmitter balance in scallops facing PST exposure.

Article Abstract

Bivalves show remarkable capacity to acclimate paralytic shellfish toxins (PSTs) produced by dinoflagellates, severely affecting fishery industry and public health. Here, transcriptomic response to PSTs-producing dinoflagellate (Alexandrium minutum) was investigated in Zhikong scallop (Chlamys farreri) mantle. The PSTs accumulated in C. farreri mantle continually increased during the 15 days exposure, with "oxidation-reduction" genes induced compared to the control group at the 1st and 15th day. Through gene co-expression network analysis, 16 PSTs-responsive modules were enriched with up- or down-regulated genes. The concentration of GTXs, major PSTs in A. minutum and accumulated in scallops, was correlated with the up-regulated magenta module, enriching peroxisome genes as the potential mantle-specific PSTs biomarker. Moreover, Hsp70B2s were inhibited throughout the exposure, which together with the expanded neurotransmitter transporter SLC6As, may play essential roles on neurotransmitter homeostasis in scallop mantle. These results paved the way for a comprehensive understanding of defensive mechanism and homeostatic response in scallop mantle against PSTs.

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Source
http://dx.doi.org/10.1016/j.marpolbul.2023.115854DOI Listing

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