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Development and Application of an In Vitro Drug Screening Assay for Schistosomula Using YOLOv5.
Biomedicines
December 2024
Infectious and Tropical Diseases Research Group (e-INTRO), Biomedical Research Institute of Salamanca, Research Centre for Tropical Diseases at the University of Salamanca (IBSAL-CIETUS), Faculty of Pharmacy, University of Salamanca, 37007 Salamanca, Spain.
Background: Schistosomiasis impacts over 230 million people globally, with 251.4 million needing treatment. The disease causes intestinal and urinary symptoms, such as hepatic fibrosis, hepatomegaly, splenomegaly, and bladder calcifications.
View Article and Find Full Text PDFCase report of rare presentation of schistosomiasis: delayed diagnosis of genitourinary schistosomiasis in an adolescent.
Pediatr Med Chir
January 2025
Department of Pediatric Surgery and Pediatric Minimally Invasive Surgery and New Technologies, San Bortolo Hospital, Vicenza.
Schistosomiasis is a tropical infection endemic to developing nations that can result in chronic liver damage, renal failure, infertility, and bladder cancer. Genitourinary localization is marked by dysuria, visible hematuria, and urinary obstruction. We present the case of a 17-year-old male adolescent from a rural area of Central Africa, who arrived in Italy two years prior, exhibiting hematuria and urinary symptoms.
View Article and Find Full Text PDFA Retrospective Study of Urinary Schistosomiasis in the Eastern Cape Province, South Africa.
Trop Med Infect Dis
November 2024
HERENDA Program, New Medical School, Walter Sisulu University, Nelson Mandela Drive, Mthatha 5100, Eastern Cape, South Africa.
Schistosomiasis is caused by infection with trematode flukes of the genus Schistosoma. More than 700 million people worldwide are estimated to be susceptible to infection. In sub-Saharan Africa, schistosomiasis is the second most widespread neglected tropical disease after malaria.
View Article and Find Full Text PDFMorbidity associated with schistosomiasis in adult population of Chókwè district, Mozambique.
PLoS Negl Trop Dis
December 2024
Institute of Hygiene and Tropical Medicine, IHMT, NOVA University, Lisbon, Portugal.
Background: Mozambique is one of the countries with the highest prevalence of schistosomiasis, although there is little data on the prevalence of disease and associated morbidity in the adult population. This study aimed to describe and characterize the morbidity associated with schistosomiasis in the adult population of Chókwè district and to explore the use of anamnestic questionnaires and urine dipsticks, as well as point-of-care ultrasound for urinary related findings, to better characterize disease prevalence and morbidity.
Methodology: Between April and October 2018, we conducted a cross-sectional study embedded within the Chókwè Health Research and Training Centre.
African Schistosomiasis: A Framework of Indicators Assessing the Transmission Risk and Intervention Effectiveness.
Trop Med Infect Dis
November 2024
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), Shanghai 200025, China.
Schistosomiasis, a parasitic disease with a complex transmission mechanism, requiring a snail intermediate host, is influenced by biology, the environment, human behavior and the prevailing socioeconomic situation. This study aimed to systematically investigate the importance and feasibility of indicators related to the factors influencing transmission and intervention measures for and . Based on a literature review and group discussions according to the Delphi method, a framework questionnaire was designed.
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