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Deciphering the Pathobiological Impairment Mechanisms of the Lymphatic System during Secondary Lymphedema Progression.
J Invest Dermatol
March 2024
Division of Plastic Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland. Electronic address:
Deciphering the regulatory mechanisms of the cAMP/protein kinase A pathway and their roles in the pathogenicity of .
Microbiol Spectr
September 2023
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.
The emergence of multidrug-resistant fungal pathogens is a significant concern for global public health. poses a considerable threat as a multidrug-resistant fungal pathogen. Our recent study revealed that the adenylyl cyclase Cyr1 and protein kinase A (PKA) pathways play distinct and redundant roles in drug resistance and pathogenicity of .
View Article and Find Full Text PDFSeeing beyond apoptosis: ultrastructural aspects of necrosis in human atherosclerosis.
Cardiovasc Pathol
November 2023
Department of Biology, Ecology and Earth Sciences, Centre for Microscopy and Microanalysis, University of Calabria, Arcavacata di Rende, Cosenza 87036, Italy. Electronic address:
In recent years, there has been an explosive growth of research to decipher the pathobiologic relevance of cell death in the development and progression of various cardiovascular disorders such as arterial remodeling and atherosclerosis. High rates of cell death have been reported in animal models, particularly following balloon catheter injury. Also, in humans there is considerable evidence indicating a close connection between cell death and atherosclerosis.
View Article and Find Full Text PDFRecent Advances in Therapeutic Modalities Against Breast Cancer-Related Lymphedema: Future Epigenetic Landscape.
Lymphat Res Biol
December 2023
Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Article Synopsis
- * This review focuses on the genetic and epigenetic factors that contribute to breast cancer-related lymphedema (BCRL), highlighting the challenges in effectively diagnosing and treating the condition.
- * The authors emphasize the need for further research on epigenetic pathways to create new therapies and improve outcomes for breast cancer survivors struggling with lymphedema.
A Predictive Model of Adaptive Resistance to BRAF/MEK Inhibitors in Melanoma.
Int J Mol Sci
May 2023
Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA.
The adaptive acquisition of resistance to BRAF and MEK inhibitor-based therapy is a common feature of melanoma cells and contributes to poor patient treatment outcomes. Leveraging insights from a proteomic study and publicly available transcriptomic data, we evaluated the predictive capacity of a gene panel corresponding to proteins differentially abundant between treatment-sensitive and treatment-resistant cell lines, deciphering predictors of treatment resistance and potential resistance mechanisms to BRAF/MEK inhibitor therapy in patient biopsy samples. From our analysis, a 13-gene signature panel, in both test and validation datasets, could identify treatment-resistant or progressed melanoma cases with an accuracy and sensitivity of over 70%.
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