Objective: This study aimed to evaluate the structural validity of the Universal Measures of Bias - Fat (UMB Fat) among Malaysian healthcare practitioners using Rasch analysis.
Methods: Data from a cross-sectional survey of 268 public and private doctors and allied health practitioners in Peninsular Malaysia were used for this analysis. Using Rasch analysis, overall model fit and item fit of the summary UMB Fat and domain scores were examined, together with unidimensionality, response threshold ordering, internal consistency, measurement invariance, and item targeting.
Results: Data showed overall misfit to the Rasch model for both the summary UMB Fat score and domain scores. Whilst unidimensionality was observed for the domain scores, this was not evident for the summary score where multiple local dependencies were present. Disordered thresholds were observed for the response format, in which the majority improved with modification. Suboptimal targeting was also detected with an uneven distribution of items at the upper and lower end of the logit scale for the summary and domain scores. Despite this, excellent internal consistency reliability was observed (person separation index: 0.76-0.89), and no measurement invariance was detected.
Conclusion: The Rasch model supports reporting of the UMB Fat domain scores but not the summary score. Several issues related to local dependencies and response format were identified that could benefit from refining the UMB Fat to improve measurement accuracy, particularly when used by healthcare practitioners in Asian countries.
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http://dx.doi.org/10.1016/j.orcp.2023.11.004 | DOI Listing |
Biochem Biophys Res Commun
January 2025
Department of Physiology, Medical University of Bialystok, Mickiewicza 2C st., 15-222, Bialystok, Poland.
α -lipoic acid (ALA) is an eight-carbon saturated fatty acid with strong antioxidant activity. Despite previous reports of ALA's protective properties in treating cardiovascular and metabolic diseases (including insulin resistance and diabetes), little is known about the compound's effects on skeletal muscle metabolism. In particular, the effect of ALA on glycooxidative and nitrosative damage in red muscles during insulin resistance is unknown.
View Article and Find Full Text PDFClin Nutr
December 2024
Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, M.C. Skłodowskiej 24a, 15-276 Białystok, Poland. Electronic address:
Background & Aims: We have recently demonstrated that subcutaneous adipose tissue (SAT) expression of genes associated with thyroid hormone (TH) action is altered in obesity and insulin resistance. The aim of the present study was to examine the effect of diet-induced weight-loss on SAT expression of genes associated with TH action.
Methods: The study group comprised 38 individuals with overweight/obesity, which completed 12-week dietary intervention program.
J Nutr Biochem
January 2025
Department of Hygiene, Epidemiology and Metabolic Disorders, Medical University of Bialystok, Bialystok, Poland. Electronic address:
Dysregulation of insulin action in hepatocytes, common in obesity, significantly contributes to insulin resistance, type 2 diabetes, and metabolic syndrome. Previous research highlights ceramides' role in these conditions. This study explores the impact of ceramides by silencing the serine palmitoyltransferase (Sptlc2) gene, crucial for the initial ceramide biosynthesis, using hydrodynamic gene delivery.
View Article and Find Full Text PDFBiomed Pharmacother
November 2024
Department of Hygiene, Epidemiology and Metabolic Disorders, Medical University of Bialystok, Bialystok, Poland. Electronic address:
Background: Liver plays a central role in systemic glucose and lipid metabolism. High-fat diet (HFD) and obesity are related to hepatic lipid accumulation and insulin resistance (InsR). Diacylglycerols (DAG) play a key role in the induction of InsR, however their involvement in hepatic InsR remains debated.
View Article and Find Full Text PDFFree Radic Biol Med
November 2024
Laboratory for Oxidative Stress, Division of Molecular Medicine, Ruder Boskovic Institute, 10000, Zagreb, Croatia. Electronic address:
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