AI Article Synopsis
- TNFAIP3 is a gene linked to systemic lupus erythematosus (SLE) risk, mostly studied in Caucasian and Asian populations, but its impact on Latin American groups is less explored.
- A study involving 561 Mexican SLE patients and 499 controls examined the TNFAIP3 rs2230926T/G variant and found a significant association of the G allele with increased SLE susceptibility.
- The results indicate that this genetic variant may serve as a risk factor for developing SLE specifically in the Mexican population.
Article Abstract
TNFAIP3 is a classical systemic lupus erythematosus (SLE)-associated risk locus identified by genome-wide association studies (GWASs) and replicated by candidate gene association studies primarily in Caucasians and Asians. However, in Latin American populations, its role on SLE susceptibility is not known. We conducted a case-control study to evaluate whether the TNFAIP3 rs2230926T/G (Phe127Cys) variant is associated with risk of developing SLE in a cohort of Mexican patients. The TNFAIP3 rs2230926T/G variant was analyzed in 561 patients with SLE and 499 control subjects, using TaqMan probes. We found that the G allele was associated with susceptibility to SLE under the allelic (OR 2.09, p = 0.005) and genotypic (OR 2.14, p = 0.004) models. In conclusion, our results show that TNFAIP3 rs2230926T/G is a risk factor for the development of SLE in the Mexican population.
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| http://dx.doi.org/10.1016/j.humimm.2023.110736 | DOI Listing |
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Article Synopsis
- TNFAIP3 is a gene linked to systemic lupus erythematosus (SLE) risk, mostly studied in Caucasian and Asian populations, but its impact on Latin American groups is less explored.
- A study involving 561 Mexican SLE patients and 499 controls examined the TNFAIP3 rs2230926T/G variant and found a significant association of the G allele with increased SLE susceptibility.
- The results indicate that this genetic variant may serve as a risk factor for developing SLE specifically in the Mexican population.
No association of eight TNFAIP3 single nucleotide variants to rheumatoid arthritis in Mexicans.
Mol Biol Rep
November 2022
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View Article and Find Full Text PDFPolymorphisms in TNFAIP3, but not in STAT4, BANK1, BLK, and TNFSF4, are associated with susceptibility to Takayasu arteritis.
Cell Immunol
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