Traditional optical design methods require designer intervention in the system's evolution from the starting point to the final design. Trial-and-error during design optimization improves system performance step by step but requires much time and effort. A new optical design framework, end-to-end fast automatic design, is proposed and achieved for the freeform reflective optics in this paper, which promotes a new optical design mode. Compared with the traditional mode through improving performance after each trial, an optical system with good image quality can be directly obtained in the end-to-end design process with simple input and no human involvement within a short time. If there is still the possibility for performance improvement of the obtained system, the designer can vary the input parameters repeatedly to obtain multiple systems with good image quality. Finally, the desired system is selected from these systems. Compared with the step-by-step trials in traditional optimization, this new optical design mode involves high-speed trials of the end-to-end automatic design process, reducing the dependence on experience and skill. In this paper, an end-to-end fast automatic design method for freeform imaging systems is developed based on a new design route. Using an initial plane system as an input, a freeform system with excellent image quality can be designed automatically within 1-2 min. After several trials of the end-to-end fast design process, three high-performance freeform systems are designed successfully that consider volume control, beam obscuration, and mirror interference.
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http://dx.doi.org/10.1364/OE.506234 | DOI Listing |
Asia Pac J Ophthalmol (Phila)
January 2025
Rescue, Repair and Regeneration Theme, UCL Institute of Ophthalmology, London, United Kingdom. Electronic address:
Purpose: Recovery rate of rod photoreceptor sensitivity (S2 gradient) following a bleach is reduced in age-related macular degeneration (AMD) due to diminished delivery of retinol across a grossly altered Bruch's membrane. Since triterpenoid saponins are known to improve transport across Bruch's, we have assessed their possible use for reversing the visual deficits in AMD.
Design: Double-blind, placebo controlled randomised clinical trial.
Asia Pac J Ophthalmol (Phila)
January 2025
Peking Union Medical College Hospital, Beijing, China. Electronic address:
Purpose: To evaluate the efficacy, durability and safety of intravitreal faricimab versus aflibercept over 48 weeks in patients with neovascular age-related macular degeneration (nAMD) from the LUCERNE China subpopulation.
Design: LUCERNE (NCT03823300) was a phase 3 global, double-masked, active comparator-controlled trial. The China subpopulation comprised patients from mainland China, Taiwan and Hong Kong.
Biosens Bioelectron
December 2024
Biophotonic Nanosensors Laboratory, Centro de Física Aplicada y Tecnología Avanzada (CFATA), Universidad Nacional Autónoma de México (UNAM), Querétaro, 76230, Mexico. Electronic address:
Smartphone-based colorimetric (bio)sensing is a promising alternative to conventional detection equipment for on-site testing, but it is often limited by sensitivity to lighting conditions. These issues are usually avoided using housings with fixed light sources, increasing the cost and complexity of the on-site test, where simplicity, portability, and affordability are a priority. In this study, we demonstrate that careful optimization of color space can significantly boost the performance of smartphone-based colorimetric sensing, enabling housing-free, illumination-invariant detection.
View Article and Find Full Text PDFAust Crit Care
January 2025
Intensive Care Medicine Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; Department of Intensive Care, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.
Background: Sleep and circadian rhythms are markedly altered in intensive care unit (ICU) patients. Numerous factors related to the patient and the ICU environment affect the ability to initiate and maintain sleep. Therefore, nonpharmacological interventions could play an essential role in improving sleep and circadian rhythm.
View Article and Find Full Text PDFMater Horiz
January 2025
Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Harbin 150040, China.
Dynamic responsive structural colored materials have drawn increased consideration in a wide range of applications, such as colorimetric sensors and high-safety tags. However, the sophisticated interactions among the individual responsive parts restrict the advanced design of multimodal responsive photonic materials. Inspired by stimuli-responsive color change in chameleon skin, a simple and effective photo-crosslinking strategy is proposed to construct hydroxypropyl cellulose (HPC) based hydrogels with multiple responsive structured colors.
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