The 2021 World Health Organization Classification of Central Nervous System Tumours introduced significant revisions to the categorization of paraspinal and nerve sheath tumours. This updated system encompasses seven tumour types: schwannoma, neurofibroma, perineurioma, hybrid nerve sheath tumours, malignant melanotic nerve sheath tumour, malignant peripheral nerve sheath tumour and cauda equina neuroendocrine tumour. This review provides an image-rich cytologic reference of these tumours, with particular emphasis on intraoperative smear preparations. Knowledge of the key cytological features of these tumours and their differential diagnoses will help guide classification of these challenging entities.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/cyt.13339 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Knee Desmoplastic Melanoma, an Uncommon Tumor, Disguised as a Malignant Peripheral Nerve Sheath Tumor: A Case Report and Review of the Literature.
Cureus
December 2024
Medical Oncology, Mohammed VI University Hospital, Oujda, MAR.
Desmoplastic melanoma is a rare and distinct subtype of cutaneous melanoma, it presents diagnostic challenges due to the lack of specific clinical features and overlapping histopathological characteristics with other malignancies, which necessitate careful clinicopathological correlation and advanced immunohistochemical profiling. While surgical excision remains the cornerstone of treatment, advances in precision medicine, particularly immune checkpoint inhibitors, have shown promise in improving outcomes for unresectable and metastatic desmoplastic melanoma. We present a case study involving a 52-year-old woman misdiagnosed with a malignant peripheral nerve sheath tumor and later identified as desmoplastic melanoma through re-evaluation of histopathological and immunohistochemical findings.
View Article and Find Full Text PDFLysophosphatidylcholine induces ceramide synthase-2 expression in primary culture model of astrocytopathy: potential therapeutic target in multiple sclerosis.
Mol Biol Rep
January 2025
Department of Pharmacology, School of Health Sciences, Central University of Punjab, Bathinda, 151401, India.
Background: Multiple sclerosis (MS) is a chronic autoimmune condition that damages the myelin sheath of neurons in the central nervous system, resulting in compromised nerve transmission and motor impairment. The astrocytopathy is considered one of the prominent etiological factor in the pathophysiology of demyelination in MS. The expression level of ceramide synthase-2 (CS-2) is yet to be established in the pathophysiology of astrocytopathy although the derailed ceramide biosynthetic pathways is well demonstrated in the pathophysiology of demyelination.
View Article and Find Full Text PDFSpatial heterogeneity in myelin sheathing impacts signaling reliability and susceptibility to injury.
eNeuro
January 2025
Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Axons in the mammalian brain show significant diversity in myelination motifs, displaying spatial heterogeneity in sheathing along individual axons and across brain regions. However, its impact on neural signaling and susceptibility to injury remains poorly understood. To address this, we leveraged cable theory and developed model axons replicating the myelin sheath distributions observed experimentally in different regions of the mouse central nervous system.
View Article and Find Full Text PDFOptic nerve sheath schwannoma: illustrative case.
J Neurosurg Case Lessons
January 2025
Department of Neurosurgery, General Hospital Bamberg, Bamberg, Germany.
Background: Optic nerve schwannomas are an extremely rare pathology in neurosurgery. Their origin is rather debatable given the structure of the optic nerve, which does not typically have Schwann cells therein. However, a number of clinical cases of optic nerve tumors classified as schwannomas have been described in the literature.
View Article and Find Full Text PDFTrigeminal Malignant Melanotic Nerve Sheath Tumor: 3-Dimensional Operative Video.
Oper Neurosurg (Hagerstown)
November 2024
Department of Neurosurgery, Stanford University, Stanford, California, USA.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!