AI Article Synopsis
- Lung tissue development in fetuses is crucial for understanding biology, but proteomic studies on developing fetal lungs are limited.
- Our analysis revealed significant changes in protein expression, including decreased metabolism-related proteins and increased cell cycle-related proteins, important for lung development.
- We identified key proteins and specific modification sites involved in lung development, enhancing our understanding and offering references for future studies in this area.
Article Abstract
Lung tissue is an important organ of the fetus, and genomic research on its development has improved our understanding of the biology of this tissue. However, the proteomic research of developing fetal lung tissue is still very scarce. We conducted comprehensive analysis of two developmental stages of fetal lung tissue of proteomics. It showed the developmental characteristics of lung tissue, such as the down-regulation of metabolism-related protein expression, the up-regulation of cell cycle-related proteins, and the regulation in proteins and pathways related to lung development. In addition, we also discovered some key core proteins related to lung development, and provided some key crotonylation modification sites that regulation during lung tissue development. Our comprehensive analysis of lung proteomics can provide a more comprehensive understanding of the developmental status of lung tissue, and provide a certain reference for future research and epigenetics of lung tissue.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691156 | PMC |
| http://dx.doi.org/10.1186/s12953-023-00215-8 | DOI Listing |
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