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| http://dx.doi.org/10.1038/s41386-023-01767-1 | DOI Listing |
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Multicellular adaptation to electrophysiological perturbations analyzed by deterministic and stochastic bioelectrical models.
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Dept. Termodinàmica, Facultat de Física, Universitat de València, Burjassot, 46100, Spain.
Cells can compensate a disruptive change in one ion channel by compensatory changes in other channels. We have simulated the adaptation of a multicellular aggregate of non-excitable cells to the electrophysiological perturbation produced by the external blocking of a cation channel. In the biophysical model employed, we consider that this blocking provokes a cell depolarization that opens a voltage-gated calcium channel, thus allowing toxic Ca levels.
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School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, Heilongjiang Province, P. R. China.
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Article Synopsis
- Long-QT syndrome type 3 (LQT3) is a cardiac ion channel disorder that increases the risk of dangerous heart rhythms, and this study aimed to create a model using human induced pluripotent stem cells (hiPSCs) to better understand the disease and test potential treatments.!
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The thienopyridine A-769662 and benzimidazole 991 inhibit human TASK-3 potassium channels in an AMPK-independent manner.
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December 2024
Centre for Discovery Brain Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK. Electronic address:
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- TASK-1/3 channels in carotid body type 1 cells are key for sensing low oxygen levels, affecting potassium currents and ultimately influencing breathing patterns.
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