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A Set of Three Gd Spin Labels with Methanethiosulfonyl Groups for Bioconjugation Covering a Wide Range of EPR Line Widths.
J Org Chem
January 2025
Faculty of Chemistry and Center for Molecular Materials (CM2), Bielefeld University, Universitätsstraße 25, Bielefeld 33615, Germany.
Spin labels based on Gd complexes are important tools for the elucidation of the structure, dynamics and interaction of biomolecules by electron paramagnetic resonance (EPR) spectroscopy. Their EPR spectroscopic properties line width and relaxation times influence their performance in a particular application. To be able to apply a complex well-suited for a specific application, a set of Gd complexes with different EPR spectroscopic properties ready-made for spin labeling will be highly useful.
View Article and Find Full Text PDF─ A User-Friendly Command-Line Tool Simplifying Differential Expression Analysis in Quantitative Proteomics.
J Proteome Res
January 2025
Functional Genomics Center Zurich (FGCZ) - University of Zurich/ETH Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Mass spectrometry is a cornerstone of quantitative proteomics, enabling relative protein quantification and differential expression analysis () of proteins. As experiments grow in complexity, involving more samples, groups, and identified proteins, interactive differential expression analysis tools become impractical. The addresses this challenge by providing a command-line interface that simplifies , making it accessible to nonprogrammers and seamlessly integrating it into workflow management systems.
View Article and Find Full Text PDFHarmonizing excellence: Crafting the nexus of competencies, standards, and degree demands in nurse practitioner education.
Nurs Outlook
January 2025
College of Health and Human Services, Department of Nursing, University of New Hampshire, Durham, NH.
Nurse practitioner (NP) programs have a long history of producing safe and competent NPs; however, bold, transformative leadership is needed to set a minimum standard for quality NP education to support a 21st-century healthcare system. This paper is a call to action for leaders in NP education to transition NP education to the DNP degree utilizing the 2022 National Task Force Standards for Quality NP Education and a competency-based approach as defined in the 2021 AACN Essentials. There is now an opportunity to redesign healthcare systems with quality and equity as a primary consideration and DNP-prepared NPs are positioned to lead this redesign.
View Article and Find Full Text PDFStage-based analysis of an adaptive worksite intervention trial for diabetes prevention.
Patient Educ Couns
January 2025
Ohio State University, Dept. of Psychology, Columbus, USA.
Objective: Stage-based models of change posit stage specific factors to promote motivation and intention formation for those not ready to change and volitional action strategies for others. The impact of two interventions on energy restriction and weight change among adults with prediabetes (n = 190) was examined by baseline stage.
Methods: Stage classification included: Pre-intenders had no intention to change; Intenders set an intention but were not acting; and Actors reported eating a low-fat diet at baseline.
Concurrent Surgical Care in an Austere Military Setting: A Preparation for Mass Casualty Events.
Mil Med
January 2025
Navy Medicine Readiness and Training Command, 620 John Paul Jones Cir, Portsmouth, VA 23708, USA.
Background: The U.S. military utilizes small, forward deployed surgical teams to provide Role 2 surgical care in austere environments.
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