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Ubiquitin and Ubiquitin-Like Modifications in Organelle Stress Signaling: Ub, Ub, Ub, Ub, Stayin' Alive, Stayin' Alive.
Bioessays
November 2024
INSERM UMR1242 Oncogenesis Stress Signaling, Université de Rennes, Rennes, France.
Due to various intracellular and external cues, cellular organelles are frequently stressed in both physiological and pathological conditions. Sensing these stresses initiates various signaling pathways which may lead to adaptation of the stressed cells or trigger its their death. At the unicellular level, this stress signaling involves a crosstalk between different organelles.
View Article and Find Full Text PDFStayin' Alive: Targeting chromatin regulators of clonal hematopoiesis promotes CD8 T cell stemness.
Cancer Res
November 2024
University of Pittsburgh Medical Center, United States.
T cell exhaustion remains a significant barrier to immunotherapeutic success for many patients with solid tumors. Growing evidence suggests that enhanced survival and self-renewal properties of a stem-like precursor T cell population (Tpex) is correlated with a survival advantage in immunotherapy. In a recent study published in Science, Kang and colleagues find three epigenetic regulators commonly mutated in clonal hematopoiesis also control Tpex progression to exhaustion.
View Article and Find Full Text PDFA A A, AAA, Stayin' Alive, Stayin' Alive: Useful for Everyone?
Eur J Vasc Endovasc Surg
May 2024
Section of Vascular Surgery, Cardio Thoracic Vascular Department, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy. Electronic address:
Usefulness of an auditory aid to improve chest compression rate accuracy during cardiopulmonary resuscitation.
J Vet Emerg Crit Care (San Antonio)
November 2023
Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.
Objective: To assess compression rate accuracy among veterinarians and registered veterinary nurses (RVNs) without and with an audible aid.
Design: Prospective study with use of a canine CPR manikin.
Setting: Small animal teaching hospital.
Stayin' alive: The introduction of municipal in-patient acute care units was associated with reduced mortality and fewer hospital readmissions.
Soc Sci Med
June 2023
Norwegian University of Science and Technology, Department of Sociology and Political Science, Edvard Bulls Veg 1, 7491 Trondheim, Norway. Electronic address:
Background: Integrated care is seen as integral in combating the current and projected resource scarcity in the healthcare systems of developed economies. Previous research finds positive effects from implementing intermediate care but there is a lack of research on how this shift towards care integration has affected traditional quality indicators within healthcare, indicators such as mortality rates and hospital readmissions. We seek to contribute to the discourse by studying how the introduction of intermediate care in the form of municipal acute units (MAUs) in Norway has affected age adjusted mortality rates and hospital readmissions.
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