AI Article Synopsis
- Esophageal squamous cell carcinoma (ESCC) evolves from normal esophageal tissue through various precancerous stages, each demonstrating distinct genomic changes.
- This study examined 1,275 micro-biopsies, revealing that TP53 biallelic inactivation occurs early in precancerous lesions, while copy number alterations (CNAs) and APOBEC mutagenesis peak later.
- The findings indicate that the loss of TP53 is a crucial early event that leads to further genetic changes associated with cancer development, highlighting its role as a key trigger in the transition to malignancy.
Article Abstract
Esophageal squamous cell carcinoma (ESCC) develops through a series of increasingly abnormal precancerous lesions. Previous studies have revealed the striking differences between normal esophageal epithelium and ESCC in copy number alterations (CNAs) and mutations in genes driving clonal expansion. However, due to limited data on early precancerous lesions, the timing of these transitions and which among them are prerequisites for malignant transformation remained unclear. Here, we analyze 1,275 micro-biopsies from normal esophagus, early and late precancerous lesions, and esophageal cancers to decipher the genomic alterations at each stage. We show that the frequency of TP53 biallelic inactivation increases dramatically in early precancerous lesion stage while CNAs and APOBEC mutagenesis substantially increase at late stages. TP53 biallelic loss is the prerequisite for the development of CNAs of genes in cell cycle, DNA repair, and apoptosis pathways, suggesting it might be one of the earliest steps initiating malignant transformation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ccell.2023.11.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Designing and incorporating integrated oral health care pathways for pediatric and adult patients: touchpoints in a dental setting.
BMC Oral Health
January 2025
National Center for Professional Training, Ministry of Health and Medical Education, Tehran, Iran.
Background: Maintenance of oral health, prevention, and health promotion stand as primary competencies for dental graduates. Consequently, it is necessary to promote such an approach in dental schools, which are traditionally focused on treatment, to improve the attitude and practice of students in the field of prevention, the final result of which is the reduction of oral and dental diseases in patients. The study aimed to design Integrated Oral Health Care Pathways (IOHCPs) for adults and children referred to Tehran University of Medical Sciences (TUMS), School of Dentistry.
View Article and Find Full Text PDFBackground: Lip and oral cavity cancer is leading cause of cancer mortality among Indian men. This study evaluated diagnostic accuracy of mobile health (mHealth) enabled screening for early detection of oral premalignant lesions or oral cancer (OPML/OC). It also described epidemiology of tobacco and other substance use and associated oral lesions in rural northern India.
View Article and Find Full Text PDFLabel credibility correction based on cell morphological differences for cervical cells classification.
Sci Rep
January 2025
Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, China.
Cervical cancer is one of the deadliest cancers that pose a significant threat to women's health. Early detection and treatment are commonly used methods to prevent cervical cancer. The use of pathological image analysis techniques for the automatic interpretation of cervical cells in pathological slides is a prominent area of research in the field of digital medicine.
View Article and Find Full Text PDFAnalysis of precancerous lesion-related microRNAs for early diagnosis of cervical cancer in the Thai population.
Sci Rep
January 2025
Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand.
The incidence rate of cervical cancer (CC) is three times greater in Southeast Asia (SEA), where screening tests are less common than in Northern America, underlining a need for convenient self-diagnostic methods. The expression pattern of microRNAs (miRNAs) has been considered a molecular tool for non-invasive cancer diagnosis and prognosis. This study aimed at the development of the first miRNA biomarker panel for early detection of CC in Thai women.
View Article and Find Full Text PDFNational Analysis of Over 48,000 Veterans With HIV Demonstrates CD4/CD8 Ratio as a Risk Marker for Anal Intraepithelial Lesions and Anal Cancer.
Dis Colon Rectum
January 2025
Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Background: Anal squamous intraepithelial lesions are identifiable and treatable precancerous lesions that lack defined risk factors determining screening necessity.
Objective: Assess the prevalence and risk factors associated with low- and high-grade anal squamous intraepithelial lesions and anal squamous cell carcinoma.
Design: Retrospective cohort analysis of veterans with HIV between 1999-2023.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!