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SeMet alleviates AFB-induced oxidative stress and apoptosis in rabbit kidney by regulating Nrf2//Keap1/NQO1 and PI3K/AKT signaling pathways. | LitMetric

The purpose of this study was to explore the protective effect of SeMet on renal injury induced by AFB in rabbits and its molecular mechanism. Forty rabbits of 35 days old were randomly divided into control group, AFB group (0.3 mg AFB/kg b.w), 0.2 mg/kg Se + AFB group (0.3 mg AFB/kg b.w + 0.2 mg SeMet/kg feed) and 0.4 mg/kg Se + AFB group (0.3 mg AFB/kg b.w + 0.4 mg SeMet/kg feed). The SeMet treatment group was fed different doses of SeMet diets every day for 21 days. On the 17-21 day, the AFB treatment group, the 0.2 mg/kg Se + AFB group and the 0.4 mg/kg Se + AFB group were administered 0.3 mg AFB /kg b.w by gavage (dissolved in 0.5 ml olive oil) respectively. The results showed that AFB poisoning resulted in the changes of renal structure, the increase of renal coefficient and serum biochemical indexes, the ascent of ROS and MDA levels, the descent of antioxidant enzyme activity, and the significant down-regulation of Nrf2, HO-1 and NQO1. Besides, AFB poisoning increased the number of renal apoptotic cells, rised the levels of PTEN, Bax, Caspase-3 and Caspase-9, and decreased the levels of PI3K, AKT, p-AKT and Bcl-2. In summary, SeMet was added to alleviate the oxidative stress injury and apoptosis of kidney induced by AFB, and the effect of 0.2 mg/kg Se + AFB is better than 0.4 mg/kg Se + AFB.

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http://dx.doi.org/10.1016/j.ecoenv.2023.115742DOI Listing

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