AI Article Synopsis
- The study analyzes the solution structure of an RNA fragment with a UUCGA pentaloop using NMR spectroscopy, revealing the formation of a UUCG tetraloop.
- It was discovered that the adenosine residue at the 3' end of the tetraloop is bulged out, a characteristic noted in other RNA structures like CUUGU and CUGGC pentaloops.
- These findings, along with the recently identified T-hairpin structure featuring a UUUGAUU loop, suggest that loop-bulge structures can be categorized as a new RNA motif called the integrated structure loop (I-loop).
Article Abstract
Although structures of many RNA loops, such as GNRA and UNCG tetraloops, were well known, it is still possible to find more RNA structures. In the present study, solution structure of an RNA fragment having UUCGA pentaloop was analyzed by NMR spectroscopy. It was found that the UUCG tetraloop is formed and the adenosine residue at the 3' side of the tetraloop is bulged out. The characteristic motif of the loop-bulge structure has also been found in other RNAs including CUUGU and CUGGC pentaloops. Along with the recently found T-hairpin structure with a UUUGAUU loop, in which UUUGA pentaloop and UU bulge are formed, the loop-bulge structures can be categorized as an RNA motif and it may be called as the integrated structure loop, I-loop.
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| http://dx.doi.org/10.1016/j.bbrc.2023.149327 | DOI Listing |
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