AI Article Synopsis
- Oral inosine loading is a new technique to study how purines affect urate metabolism, but individual responses vary and the effects on other purines are still not well understood.
- In a study with 35 male participants, blood and urine samples were collected after they took 500 mg of inosine to see how it impacted their urate levels over 180 minutes.
- Results showed that initial urate levels differed between hyperuricemia and non-hyperuricemia groups, but there was no significant change post-ingestion; however, a higher estimated glomerular filtration rate (eGFR) correlated with greater urate increases, likely due to elevated xanthine oxidase levels.
Article Abstract
Background: Oral inosine loading is a new method to evaluate the effects of purine on urate metabolism. However, individuals respond differently to acute purine intake, and the effects on the metabolism of other purines remain to be explored.
Methods: 35 male participants are recruited. Participants received 500 mg of inosine orally after an overnight fast, and blood and urine samples are collected before and at various time points over 180 min after inosine administration.
Results: The serum urate concentration is significantly different between the hyperuricemia (n = 14) and non-hyperuricemia (n = 16) groups before inosine intake, but there is no in urate change after inosine intake. When grouped according to the baseline estimated glomerular filtration rate (eGFR), the increase in urate level in the high-eGFR group is significantly higher than that in the low-eGFR group (p = 0.047). The high-eGFR group showed higher levels of serum xanthine and xanthine oxidase (XOD), the key enzyme in urate synthesis, after inosine loading (p < 0.01).
Conclusions: The increase in urate level is positively related to eGFR after oral acute inosine administration, which may have been due to a higher level of XOD.
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| http://dx.doi.org/10.1002/mnfr.202300115 | DOI Listing |
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