Various correlations hidden in crowdsourcing annotation tasks bring opportunities to further improve the accuracy of label aggregation. However, these relationships are usually extremely difficult to be modeled. Most existing methods can merely make use of one or two correlations. In this paper, we propose a novel graph neural network model, namely LAGNN, which models five different correlations in crowdsourced annotation tasks by utilizing deep graph neural networks with convolution operations and derives a high label aggregation performance. Utilizing the group of high quality workers through labeling similarity, LAGNN can efficiently revise the preference among workers. Moreover, by injecting a little ground truth in its training stage, the label aggregation performance of LAGNN can be further significantly improved. We evaluate LAGNN on a large number of simulated datasets generated through varying six degrees of freedom and on eight real-world crowdsourcing datasets in both supervised and unsupervised (agnostic) modes. Experiments on data leakage is also contained. Experimental results consistently show that the proposed LAGNN significantly outperforms six state-of-the-art models in terms of label aggregation accuracy.
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http://dx.doi.org/10.1109/TPAMI.2023.3338216 | DOI Listing |
Sci Rep
March 2025
Department of Mathematical Sciences, United Arab Emirates University, P. O. Box 15551, Al-Ain, United Arab Emirates.
The neutrosophic hesitant fuzzy set is the union of the neutrosophic set and hesitant fuzzy set in which each element has membership, neutrality, and non-membership arrays which verifies infrequency in labeling uncertainty in daily usage. We proposed two novel operators in this analysis that demonstrate evolution, one is the neutrosophic hesitant fuzzy partitioned Maclaurin symmetric mean (NHFPMSM) and the other is the neutrosophic hesitant fuzzy weighted partitioned Maclaurin symmetric mean (NHFWPMSM). These novels aim to draw inspiration from the partitioned Maclaurin symmetric mean concept.
View Article and Find Full Text PDFJ Neurochem
March 2025
Queen Square Institute of Neurology, UCL and The National Hospital for Neurology and Neurosurgery, London, UK.
Neurodegeneration presents a significant challenge in ageing populations, often being detected too late for effective intervention. Biomarkers have shown great potential in addressing this issue, with neurofilament (Nf) proteins emerging as validated biomarkers presently transitioning from research to routine laboratory use. Whilst advances in large-scale quantitative analyses have enabled the targeted study of proteolytic Nf fragments in blood, the complete landscape of the Nf proteolytic breakdown remains unknown.
View Article and Find Full Text PDFSmall Methods
March 2025
School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai, 201203, P. R. China.
Elucidating in vivo lipolysis is crucial for clarifying the underlying mechanisms and in vivo fates of lipid-based nanocarriers, which are essential oral drug delivery carriers. Current mainstream methodologies use various in vitro digestion models to predict the in vivo performance of lipid formulations; however, their accuracy is often impeded by the complicated environment of the gastrointestinal tract. Although fluorescence labeling with conventional probes partly reveals the in vivo translocation of lipid nanocarriers, it fails to elucidate the lipolysis process because of poor signal discrimination among nanocarriers, free probes, and mixed micelles (lipolysis end-products).
View Article and Find Full Text PDFMikrochim Acta
March 2025
School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, P. R. China.
The phosphorylation of nucleic acids mediated by 5'-polynucleotide kinase (PNK) exerts a crucial regulatory function in a wide range of significant cellular activities. Nevertheless, the current approaches for detecting PNK require expensive labeled probes and complex instrumentation, making it impossible to achieve real-time, on-site, and rapid analysis. Here, we take T4 PNK as a model and establish a novel colorimetric strategy for the detection of PNK activity and its inhibition by means of a coupled enzyme-assisted cyclic strand displacement amplification (SDA) and peptide nucleic acid (PNA)-gold nanoparticle (AuNP) based platform.
View Article and Find Full Text PDFAnal Bioanal Chem
March 2025
Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, China.
Early diagnosis of human immunodeficiency virus (HIV) is critical for effective treatment; however, traditional antibody methods encounter challenges during the infection window, and nucleic acid tests require specialized equipment. In this study, a dual-mode ribonucleic acid (RNA)-splitting aptamer biosensor was developed to target the HIV trans-activator of transcription (Tat) protein, a key HIV biomarker for viral replication throughout the infection cycle. The biosensor integrates colorimetric and fluorescent detection techniques by utilizing gold nanoparticles (AuNPs) and two types of aptamers, one labeled with carboxyfluorescein (FAM).
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