PD1-blockade combinations in pancreatic ductal adenocarcinoma have been poorly effective, and the underlying reasons for this are unknown. A recent study revealed that chemoradiation plus PD1-blockade reinvigorates tumor-specific T cells; however, this T-cell activation is accompanied with exaggerated NFκB signaling, which may limit productive tumor-controlling immunity. See related article by Ali et al., p. 542.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10842790 | PMC |
| http://dx.doi.org/10.1158/1078-0432.CCR-23-2991 | DOI Listing |
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