AI Article Synopsis
- * CSFV NS5A disrupts the interaction between PP2A and Beclin 1 and instead ties PP2A to DAPK3, leading to the activation of autophagy.
- * This study uncovers a new way CSFV hijacks the autophagy system, which could inform future antiviral treatments.
Article Abstract
Autophagy is a conserved degradation process that maintains cellular homeostasis and regulates native and adaptive immunity. Viruses have evolved diverse strategies to inhibit or activate autophagy for their benefit. The paper reveals that CSFV NS5A mediates the dissociation of PP2A from Beclin 1 and the association of PP2A with DAPK3 by interaction with PPP2R1A and DAPK3, PP2A dephosphorylates DAPK3 to activate its protein kinase activity, and activated DAPK3 phosphorylates Beclin 1 to trigger autophagy, indicating that NS5A activates autophagy via the PP2A-DAPK3-Beclin 1 axis. These data highlight a novel mechanism by which CSFV activates autophagy to favor its replication, thereby contributing to the development of antiviral strategies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734420 | PMC |
| http://dx.doi.org/10.1128/jvi.00988-23 | DOI Listing |
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