AI Article Synopsis
- The excessive use of chlorhexidine gluconate (CHG) can harm the environment and human health, prompting the need to explore plant-derived compounds that can enhance its effectiveness.
- Antiviral tests demonstrated that combining CHG with salicylic acid significantly reduced the amount of CHG needed to effectively combat viruses like HSV-1, H1N1, and Ad-5, leading to faster inactivation times.
- The study concludes that this combination not only boosts antiviral efficacy at lower doses but also protects CHG's effectiveness against other substances, showcasing its potential for improved infection management.
Article Abstract
Background: The excessive usage of chlorhexidine gluconate (CHG) as a broad-spectrum antimicrobial reagent can have a negative impact on the environment and on human health. The aim of this study was to investigate the effectiveness of some plant-derived compounds in reducing the CHG concentration required to exert its antiviral activity.
Methods: Antiviral assays were conducted according to EN 14476 (2019) against herpes simplex virus type 1 (HSV-1), H1N1 influenza A virus, and adenovirus type 5 (Ad-5) as enveloped and non-enveloped viral models to assess the synergistic interaction of CHG and natural additive compounds.
Results: The effective concentration of 0.247 mM CHG against HSV-1 was decreased tenfold in combination with 0.0125 mM salicylic acid, with a titer reduction of 1.47 ⋅ 10 CCID/ml. The time required for complete inactivation of HSV-1 particles was reduced to 15 min when the virus was exposed to 0.061 mM CHG and 0.0125 mM salicylic acid. Additionally, the presence of salicylic acid protected the CHG activity against interfering substances.
Conclusion: Our supplemented CHG formulation showed immediate antiviral effectiveness, which is important for management of the infections. CHG can be combined with salicylic acid to exhibit synergistic antiviral activity at lower concentrations and reduce the time required for inactivation. Furthermore, in the presence of interfering substances, the combination has higher antiviral activity than CHG alone.
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| http://dx.doi.org/10.1007/s00705-023-05932-1 | DOI Listing |
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