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Pulmonary subsolid nodules: upfront surgery or watchful waiting?
Chest
January 2025
Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing, China. Electronic address:
Background: Patients with pulmonary subsolid nodules (SSNs) ≤ 2 cm in diameter and a consolidation-to-tumor ratio (CTR) ≤ 0.25 have good postoperative prognoses, but their management remains controversial.
Research Question: Does upfront surgical intervention lead to higher survival than watchful waiting in patients with SSNs diameter ≤ 2 cm and CTR ≤ 0.
EGFR Mutation Rates Correlate with Age at Diagnosis and Tumor Characteristics in Patients with Pulmonary Ground-Glass Opacities.
Ann Surg Oncol
December 2024
Department of Cardiothoracic Surgery, Zhongshan City People's Hospital, Zhongshan, Guangdong, People's Republic of China.
Background: To clearly reveal the correlations between tumor characteristics, age at diagnosis, and epidermal growth factor receptor (EGFR) mutation rates in patients with pulmonary ground-glass opacities (GGOs).
Methods: We retrospectively reviewed 1473 patients with GGOs between January 2015 and May 2020 from two cancer centers. The tumor characteristics and EGFR mutation rates were compared between different age groups.
Diagnostic artificial intelligence model predicts lymph node status in non-small cell lung cancer using simplified examination.
J Thorac Dis
November 2024
Department of Thoracic Surgery, School of Medicine, Iwate Medical University, Iwate, Japan.
Background: Artificial intelligence (AI) technology was introduced in medical data area and applied disease prediction models. This study aimed to establish an AI model for predicting lymph node metastasis based on simple medical examinations in patients with non-small cell lung cancer (NSCLC).
Methods: We retrospectively analyzed 988 patients with NSCLC who underwent radical pulmonary resection with mediastinal lymph node dissection between January 2011 and October 2022.
Prognostic impact of mutations in T1-4N0M0 lung adenocarcinoma: analyses focus on imaging and pathological features.
J Thorac Dis
November 2024
Department of Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Background: With the development of tyrosine kinase inhibitor (TKI) treatment, the prognosis of advanced lung adenocarcinoma (LUAD) patients with epidermal growth factor receptor () mutations has been continuously improving. This study aims to propose the utilization of pathological characteristics and imaging features to evaluate the impact of gene mutations on the prognosis of T1-4N0M0 LUAD.
Methods: Among the cases diagnosed with LUAD between April 2015 and April 2016, 438 patients with T1-4N0M0 LUAD were included, and the clinical characteristics were collected.
Predicting Recurrence after Sublobar Resection in Patients with Lung Adenocarcinoma Using Preoperative Chest CT Scans.
Radiology
October 2024
From the Departments of Thoracic and Cardiovascular Surgery (J.K.Y., J.Y.K., G.D.L., S.C., Y.H.K., D.K.K., S.I.P., H.R.K.) and Radiology (Y.A., M.Y.K.), Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro, 43-gil, Songpa-gu, Seoul 05505, Republic of Korea.
Background Sublobar resection for lung cancer is usually guided by cutoff values for consolidation size (maximal diameter of the solid tumor component) and consolidation-to-tumor ratio (CTR). The effects of these factors as continuous variables and the reason for established cutoffs are, to the knowledge of the authors, unexplored. Purpose To quantitatively assess the predictive value of CTR and consolidation size for cancer recurrence risk after sublobar resection in clinical stage IA lung adenocarcinoma.
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