Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jhep.2023.11.014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Study Question: Can a genome-wide association study (GWAS) and transcriptome-wide association study (TWAS) help identify genetic variation or genes associated with circulating anti-Müllerian hormone (AMH) levels in Samoan women?
Summary Answer: We identified eleven genome-wide suggestive loci (strongest association signal in 19-946163-G-C [ = 2.32 × 10⁻⁷]) and seven transcriptome-wide significant genes ( [all with a < 2.50 × 10⁻⁶]) associated with circulating AMH levels in Samoan women.
Cranial neural crest (CNC) cells are key stem cells that contribute to most of the facial structures in vertebrates. ADAM ( A D isintegrin A nd M etalloprotease) proteins are essential for the induction and migration of the CNC. We have shown that Adam13 associates with the transcription factor Arid3a to regulate gene expression.
View Article and Find Full Text PDFReply to: "ARID3A variant and the risk of primary biliary cholangitis in a Central European cohort".
J Hepatol
June 2024
Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China. Electronic address:
ARID3A variant and the risk of primary biliary cholangitis in a Central European cohort.
J Hepatol
June 2024
Laboratory of Metabolic Liver Diseases, Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland; Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany. Electronic address:
A regulatory variant at 19p13.3 is associated with primary biliary cholangitis risk and ARID3A expression.
Nat Commun
March 2023
Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai, China.
Genome-wide association studies have identified 19p13.3 locus associated with primary biliary cholangitis (PBC). Here we aim to identify causative variant(s) and initiate efforts to define the mechanism by which the 19p13.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!