AI Article Synopsis
- SARS-CoV-2 infections were common among vaccinated pediatric solid organ transplant recipients (pSOTRs) during the Omicron period, even with strong anti-RBD antibody responses.
- The findings indicate that while pSOTRs generated good antibody responses, these antibodies had limited effectiveness in neutralizing Omicron subvariants.
- Breakthrough infections in this group tended to be relatively mild in terms of severity.
Article Abstract
SARS-CoV-2 infection during the Omicron period was frequent amongst a cohort of vaccinated pediatric solid organ transplant recipients (pSOTRs) despite robust anti-receptor-binding domain (anti-RBD) antibody response, suggesting poor neutralizing capacity against Omicron subvariants. Breakthrough infections among pSOTRs were overall limited in severity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10896257 | PMC |
| http://dx.doi.org/10.1093/jpids/piad108 | DOI Listing |
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