New N-amino acid derivatives of daunorubicin have been obtained by acylation of daunorubicin amino group with alpha, beta, and gamma amino acids and their N,N-dibenzyl derivatives. The results of the antitumor activity determination have evidenced that the change of the amino function position in the daunorubicin derivatives, in relation to that of the parent antibiotic, causes the loss of activity.
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High-altitude exposure can adversely affect neurocognitive functions; however, the underlying mechanisms remain elusive. Why and how does high-altitude exposure impair neurocognitive functions, particularly sleep? This study seeks to identify the molecular markers and mechanisms involved, with the goal of forming prevention and mitigation strategies for altitude sickness. Using serum proteomics and metabolomics, we analyzed blood samples from 23 Han Chinese plain dwellers before and after six months of high-altitude work in Tibet.
View Article and Find Full Text PDFRapamycin-loaded nanostructured lipid carrier modified with folic acid intended for breast cancer therapy.
Int J Pharm
January 2025
School of Pharmaceutical Science of São Paulo State University (UNESP), Araraquara, Sao Paulo, Brazil. Electronic address:
Breast cancer stands as the most common form of malignancy among women globally, and it showcases commendable rates of cure when detected in early-stage and non-metastatic conditions. To overcome drug resistance and side effects observed in conventional chemotherapy, the present study aims to deliver rapamycin (RAP), a mTOR protein inhibitor, into a nanostructured lipid carrier (NLC) functionalized with folic acid for promoting active targeting to breast cancer cells. In the first step, the synthesis of 1,2-distearoyl-sn-glycero-3-phosphatidylethanolamine-N-[amino(polyethylene glycol)-2000] (ammonium salt) with folic acid (DSPE-PEG-FA) was successfully performed and characterized by UV spectroscopy, nuclear magnetic resonance, and infrared spectroscopy.
View Article and Find Full Text PDFUltrasound-responsive nanocarriers with siRNA and FeO regulate macrophage polarization and phagocytosis for augmented non-small cell lung cancer immunotherapy.
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November 2024
School of Grassland Science, Beijing Forestry University, Beijing, 100083, China; Department of Natural Resources, Cornell University, Ithaca, NY, 14853, United States. Electronic address:
Article Synopsis
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Polymer Science and Engineering Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.
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