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Enhancing Neuroprotection After Cardiac Arrest: The Potential of Hydrogen Inhalation and Therapeutic Hypothermia.
Crit Care Med
January 2025
Both authors: Graduate School of Tianjin Medical University, Tianjin Medical University, Tianjin, China.
Hypothermia improves neuronal network recovery in a human-derived in vitro model of oxygen-deprivation.
PLoS One
December 2024
Department of Clinical Neurophysiology, University of Twente, Enschede, The Netherlands.
Mild therapeutic hypothermia showed potential neuroprotective properties during and after cerebral hypoxia or ischemia in experimental animal studies. However, in clinical trials, where hypothermia is mainly applied after reperfusion, results were divergent and neurophysiological effects unclear. In our current study, we employed human-derived neuronal networks to investigate how treatment with hypothermia during hypoxia influences neuronal functionality and whether it improves post-hypoxic recovery.
View Article and Find Full Text PDFTemperature induces brain-intake shift of recombinant high-density lipoprotein after traumatic brain injury.
J Nanobiotechnology
December 2024
Brain Injury Center, Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China.
Traumatic brain injury (TBI) is one of the leading public health concerns in the world. Therapeutic hypothermia is routinely used in severe TBI, and pathophysiological hyperthermia, frequently observed in TBI patients, has an unclear impact on drug transport in the injured brain due to a lack of study on its effects. We investigated the effect of post-traumatic therapeutic hypothermia at 33°C and pathophysiological hyperthermia at 39°C on brain transport and cell uptake of neuroprotectants after TBI.
View Article and Find Full Text PDFTherapeutic Hypothermia and Its Role in Preserving Brain Volume in Term Neonates with Perinatal Asphyxia.
J Clin Med
November 2024
Automatics Research Group, Technologic University of Pereira, Pereira 660003, Colombia.
Perinatal asphyxia is a major cause of neonatal morbidity and mortality, often resulting in hypoxic-ischemic encephalopathy (HIE) with long-term neurodevelopmental impairments. While therapeutic hypothermia has emerged as a promising intervention to reduce brain damage, its specific impact on key brain structures and long-term neurodevelopmental outcomes remains underexplored. This study aims to evaluate the effects of therapeutic hypothermia on brain volumetry, cortical thickness, and neurodevelopment in term neonates with perinatal asphyxia.
View Article and Find Full Text PDFSystemic Hypothermia in the Acute Management of Traumatic Optic Neuropathy in a Murine Animal Model.
Ophthalmic Plast Reconstr Surg
December 2024
Department of Ophthalmology, Dr. Nasser Al-Rashid Orbital Vision Research Center, Bascom Palmer Eye Institute, University of Miami, Miami, Florida, U.S.A.
Purpose: To examine the effects of systemic hypothermia on retinal ganglion cell survival and visual outcomes after optic nerve trauma in a sonication-inducted traumatic optic neuropathy murine animal model.
Methods: Twenty mice underwent sonication-inducted traumatic optic neuropathy. Afterward, 10 mice were placed on a warming pad set to 36°C, and 10 mice were placed on a table.
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