Previous studies of natural variants in implicated the Wnt signaling receptor in sleep. Given that the Wnt signaling pathway is highly conserved across species, we hypothesized that (), the murine homolog of , would also have a role in sleep. Using a CRISPR transgenic approach, we removed most of the coding region from C57BL/6N mice. We used a video assay to measure sleep characteristics in -deficient mice. As signaling is known to affect visuospatial memory, we also examined the impact of the deletion on learning and memory using the novel object recognition (NOR) paradigm. -deficient mice had altered sleep compared to littermate controls. The mice did not respond differently to the NOR paradigm compared to controls but did display anxiety-like behavior. Our strategy demonstrates that the study of natural variation in sleep translates into candidate genes for sleep in vertebrate species such as the mouse.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10684271 | PMC |
| http://dx.doi.org/10.1093/sleepadvances/zpad045 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The association among individual gray matter volume of frontal-limbic circuitry, fatigue susceptibility, and comorbid neuropsychiatric symptoms following COVID-19.
Neuroimage
January 2025
Department of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. Electronic address:
Article Synopsis
- The study investigates the neurobiological factors that make individuals susceptible to fatigue after a mild COVID-19 infection, aiming to understand the link between brain structure and post-COVID neuropsychiatric symptoms.
- Researchers used neuropsychiatric assessments and MRI scans on individuals who had COVID-19 and a control group to analyze brain regions related to fatigue.
- Results indicate that specific brain areas, particularly the right dorsolateral prefrontal cortex, are linked to fatigue severity and can predict ongoing fatigue symptoms months after the infection, shedding light on the neural underpinnings of post-COVID conditions.
Simultaneous activation of different subtypes of dopamine receptors may lead to activation of homeostatic sleep regulatory mechanisms.
Pharmacol Biochem Behav
January 2025
In vivo Electrophysiology Research Group, Department of Physiology and Neurobiology, Eötvös Loránd University, Hungary. Electronic address:
Dopaminergic system gains importance in homeostatic sleep regulation, but the role of different dopamine receptors is not well-defined. 72 h rat electrocorticogram and sleep recordings were made after single application of dopaminergic drugs in clinical use or at least underwent clinical trials. The non-selective agonist apomorphine evoked short pharmacological sleep deprivation with intense wakefulness followed by pronounced sleep rebound.
View Article and Find Full Text PDFParental impact on adherence of young children to 24-h movement behaviour guidelines: the Czech FAMIly Physical Activity, Sedentary behaviour and Sleep study.
Eur J Public Health
January 2025
Institute of Active Lifestyle, Faculty of Physical Culture, Palacký University Olomouc, Olomouc, Czech Republic.
Human movement behaviour typically unfolds in 24-h cycles, with children being additionally influenced by their parents. Therefore, the aim of this study was to investigate the adherence of 3-10-year-old children to the World Health Organization's (WHO) 24-h movement behaviour guidelines in relation to the behaviours of their mothers/fathers. Data from the Czech cross-sectional FAMIly Physical Activity, Sedentary behaviour and Sleep study included 381 families (with at least one child aged 3-10 years) from urban and rural areas across all three regions of Czechia.
View Article and Find Full Text PDFUnveiling the Role of TBK1 as a Novel Biomarker in Obstructive Sleep Apnea Syndrome.
Sleep
January 2025
Department of Clinical Nutrition, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Evaluation of sleep disorders in children and adolescents affected by Klinefelter syndrome.
Eur J Pediatr
January 2025
Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Unlabelled: Klinefelter syndrome (KS) is the most common sex chromosomal aneuploidy in males (47,XXY karyotype in 80-90% of cases), primarily characterized by hypergonadotropic hypogonadism and infertility. It encompasses a broad phenotypic spectrum, leading to variability in neurocognitive and psychosocial outcomes among affected individuals. Despite the recognized correlation between KS and various neuropsychiatric conditions, studies investigating potential sleep disorders, particularly in pediatric subjects, are lacking.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!