Encephalitis occasionally occurs due to the central nervous system (CNS) infection by Varicella-zoster virus (VZV). The coincidence of herpes Encephalitis-brain infection and brucellosis occurs rarely. In this case, a 56-year-old woman was described with low consciousness, seizures, fever, and mood disorders. The brain CT revealed no pathological lesions, but MR showed non-specific plaques in the periventricular white matter. VZV was detected in molecular tests for the panel of viral Encephalitis in cerebrospinal fluid (CSF). The blood culture and the Wright test revealed the presence of . The antiviral treatment of choice was Acyclovir, Levetiracetam to control seizures, and Ampicillin/Sulbactam as prophylaxis antibiotics. Coinfections common poor prognoses makes it crucial to administer antiviral medications immediately. Many clinical challenges require a multidisciplinary team, including involvement of the CNS, resistance to viral strains, reactivation of diseases, and drug toxicity. The early detection of Encephalitis and treatment can promptly prevent exacerbation and complications.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686003 | PMC |
| http://dx.doi.org/10.1093/omcr/omad121 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cerebral Hemorrhage in Varicella-Zoster Virus Encephalitis: A Case Study.
Am J Case Rep
January 2025
Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
BACKGROUND Varicella-zoster virus (VZV) encephalitis is a commonly reported form of encephalitis that clinically manifests as skin lesions, fever, headache, and neuropsychiatric symptoms. We present a case of a patient with VZV encephalitis complicated by cerebral hemorrhagic transformation, characterized by high levels of inflammation and protein in the cerebrospinal fluid. The aim is to highlight the risk of hemorrhagic transformation associated with VZV encephalitis.
View Article and Find Full Text PDFRamsay Hunt Syndrome With Multiple Cranial Neuropathies, Meningitis, and Subsequent Brainstem Encephalitis: A Case Report.
Cureus
November 2024
Otolaryngology, Oita University, Yufu, JPN.
We present a case of Ramsay Hunt syndrome in a previously healthy 49-year-old male, complicated by ipsilateral glossopharyngeal, vagus, accessory, and hypoglossal nerve palsies, along with meningitis. Despite a course of antiviral therapy and steroids for meningitis, the patient experienced a relapse, developing varicella-zoster virus (VZV) brainstem encephalitis after an initial period of stability. Hunt syndrome can be encountered in otolaryngology and internal medicine, dermatology, and other specialties.
View Article and Find Full Text PDFOptimization of antiviral dosing in Herpesviridae encephalitis: a promising approach to improve outcome?
Clin Microbiol Infect
December 2024
Institute of Medical Microbiology and Virology, University Medical Center, Göttingen, Germany.
Background: Despite established antiviral therapy for herpes simplex virus, varicella zoster and cytomegalovirus encephalitis, the outcome remains poor.
Objectives: To assess pharmacokinetic (PK) and pharmacodynamic (PD) data of antiviral drugs in the central nervous system (CNS) to optimize the treatment of Herpesviridae encephalitis.
Sources: PUBMED search 1950 to September 2024, terms (1) "encephalitis" and ("HSV" or "VZV" or "CMV") or (2) cerebrospinal and ("(val)acyclovir" or "(val)ganciclovir" or "foscarnet" or "cidofovir").
Varicella zoster meningoencephalitis without exanthem: immunocompetent host.
J Pak Med Assoc
December 2024
Department of Anaesthesiology, Aga Khan University Hospital, Karachi, Pakistan.
In an immunocompetent person, varicella zoster virus (VZV) is an uncommon cause of aseptic meningoencephalitis. Reactivation of the latent varicella zoster virus from nerve infection results in shingles, a condition marked by rash, intense pain, and dermal involvement in immunocompromised hosts. We present an unusual case of a 22-year-old immunocompetent male diagnosed as VZV meningoencephalitis without exanthem.
View Article and Find Full Text PDFThe Role of Varicella Zoster Virus (VZV) in Central Nervous System Infectious Syndromes.
Can J Infect Dis Med Microbiol
November 2024
Infection Diseases Department, Kaplan Medical Center, Rehovot, Israel.
We describe the proportion of VZV infection in central nervous system (CNS) infectious syndromes in a single Israeli medical center. An observational cohort study was conducted in Kaplan Medical Center (a secondary hospital, Israel) between July 1, 2014, and March 31, 2019. Included were adult patients (≥ 16 years old) with CNS infection with an aseptic CSF profile that were subjected to molecular tests for herpes viruses, HSV either 1 or 2, VZV, enteroviruses, and IgM for West Nile virus (WNV).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!