AI Article Synopsis
- B-cell maturation antigen (BCMA) CAR T cells are recognized as the most effective treatment for multiple myeloma (MM), with a growing body of research supporting their use in first-line therapy strategies.
- Clinical and preclinical studies emphasize the importance of assessing BCMA expression for better patient selection and monitoring, leading to improved management of the disease and its side effects.
- Advancements in CAR T-cell manufacturing processes aim to enhance patient access to these therapies, fostering the goal of curing multiple myeloma.
Article Abstract
B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cells are the most potent treatment against multiple myeloma (MM). Here, we review the increasing body of clinical and correlative preclinical data that support their inclusion into firstline therapy and sequencing before T-cell-engaging antibodies. The ambition to cure MM with (BCMA-)CAR T cells is informed by genomic and phenotypic analysis that assess BCMA expression for patient stratification and monitoring, steadily improving early diagnosis and management of side effects, and advances in rapid, scalable CAR T-cell manufacturing to improve access.
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| http://dx.doi.org/10.1182/blood.2023021221 | DOI Listing |
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