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Low-Fouling and Antibacterial Polymer Brushes via Surface-Initiated Polymerization of a Mixed Zwitterionic and Cationic Monomer. | LitMetric

AI Article Synopsis

  • The report discusses a novel styrene derivative that combines quaternary ammonium and sulfobetaine groups to create polymer brushes with both antibacterial and low-fouling properties.
  • Surface-initiated polymerization techniques were used to graft these dual-function brushes onto titanium and polyethylene materials, resulting in thick, charged polymer layers.
  • The resulting polymer brushes demonstrated strong antibacterial activity against various bacteria and effective antifouling properties, highlighting the benefits of integrating these functionalities into a single monomer.

Article Abstract

The use of surface-grafted polymer brushes with combined low-fouling and antibacterial functionality is an attractive strategy to fight biofilm formation. This report describes a new styrene derivative combining a quaternary ammonium group with a sulfobetaine group in one monomer. Surface-initiated polymerization of this monomer on titanium and a polyethylene (PE) base material gave bifunctional polymer brush layers. Grafting was achieved via surface-initiated atom transfer radical polymerization from titanium or heat-induced free-radical polymerization from plasma-activated PE. Both techniques gave charged polymer layers with a thickness of over 750 nm, as confirmed by ToF-SIMS-SPM measurements. The chemical composition of the brush polymers was confirmed by XPS and FT-IR analysis. The surface charge, characterized by the ζ potential, was positive at different pH values, and the number of solvent-accessible excess ammonium groups was found to be ∼10 N/cm. This led to strong antibacterial activity against Gram-positive and Gram-negative bacteria that was superior to a structurally related contact-active polymeric quaternary ammonium brush. In addition to this antibacterial activity, good low-fouling properties of the dual-function polymer brushes against Gram-positive and Gram-negative bacteria were found. This dual functionality is most likely due to the combination of antibacterial quaternary ammonium groups with antifouling sulfobetaines. The combination of both groups in one monomer allows the preparation of bifunctional brush polymers with operationally simple polymerization techniques.

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Source
http://dx.doi.org/10.1021/acs.langmuir.3c02657DOI Listing

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