AI Article Synopsis
- The study aimed to compare ciliary muscle thickness (CMT) between individuals with low myopia and high myopia using advanced imaging techniques.
- It involved 40 young adults, dividing them into low myopia (SER -0.50 D to -3.00 D) and high myopia (SER ≤ -6.00 D) groups, measuring CMT at different positions.
- Results indicated that high myopes had thicker CMT at certain points but thinner overall maximum CMT compared to low myopes, suggesting structural differences in muscle as myopia progresses.*
Article Abstract
Objective: To characterize and compare the ciliary muscle thickness (CMT) between low and high myopes using swept-source anterior segment optical coherence tomography (AS-OCT).
Methods: Forty visually healthy young Chinese adults aged 18-25 years were divided into two groups based on refractive errors: low myopia (n = 20, spherical-equivalent refractive error (SER) between -0.50 D to -3.00 D) and high myopia (n = 20, SER ≤ -6.00 D). Cycloplegic refractions were performed before axial length (AL) and CMT were measured using a partial coherence laser interferometer and an AS-OCT respectively. CMT was measured perpendicularly to the sclera-ciliary muscle interface at 1 mm (CMT_1), 2 mm (CMT_2), and 3 mm (CMT_3) posterior to the scleral spur, and at the location with maximal thickness (CMT_MAX).
Results: High myopes demonstrated thicker CMT at 2 mm (CMT_2, p = 0.035) and 3 mm (CMT_3, p = 0.003) posterior to the scleral spur, but thinner maximal CMT (CMT_MAX, p = 0.005) than low myopes. The apical CMT_1 and CMT_MAX were also thinner in high myopes than in low myopes (both p< 0.001). CMT_MAX, apical CMT_1, and apical CMT_MAX correlated directly with SER and inversely with AL; in contrast, CMT_2 and CMT_3 showed inverse correlations with SER but direct correlations with AL.
Conclusion: Our findings revealed significant differences in CMT between low and high myopes, with high myopes showing thicker CMT at 2 mm and 3 mm posterior to the scleral spur, but thinner maximal CMT. These results provide new evidence of the potential structural differences in ciliary muscles during myopia development and progression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688841 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0289135 | PLOS |
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