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Spatially-resolved analyses of muscle invasive bladder cancer microenvironment unveil a distinct fibroblast cluster associated with prognosis.
Front Immunol
January 2025
Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Background: Muscle-invasive bladder cancer (MIBC) is a prevalent cancer characterized by molecular and clinical heterogeneity. Assessing the spatial heterogeneity of the MIBC microenvironment is crucial to understand its clinical significance.
Methods: In this study, we used imaging mass cytometry (IMC) to assess the spatial heterogeneity of MIBC microenvironment across 185 regions of interest in 40 tissue samples.
Mesothelioma survival prediction based on a six-gene transcriptomic signature.
iScience
October 2024
National Centre for Asbestos Related Diseases, University of Western Australia, Nedlands, WA, Australia.
Mesothelioma is a lethal cancer. Despite promising outcomes associated with immunotherapy, durable responses remain restricted to a minority of patients, highlighting the need for improved strategies that better predict outcome. Here, we described the development of a mesothelioma-specific gene signature that accurately predicts survival.
View Article and Find Full Text PDFCytologic diagnosis and differential diagnosis of histiocytic signet ring cells in effusion specimens.
Cytojournal
September 2024
Department of Pathology, The Johns Hopkins Hospital, Baltimore, United States.
Article Synopsis
- The study investigates benign histiocytic proliferation in effusions, noting its similarities to diseases like rheumatoid arthritis and lupus, while highlighting potential confusion with malignant tumors.
- Out of 755 benign effusion cases analyzed over a year, 35 cases exhibited histiocytic signet ring cell features, emphasizing the importance of correct diagnosis.
- Key characteristics of these benign histiocytes include clear cytoplasm, eccentric nuclei, and a specific morphology that distinguishes them from malignant cells, confirmed through immunohistochemical staining.
Crispr-mediated genome editing reveals a preponderance of non-oncogene addictions as targetable vulnerabilities in pleural mesothelioma.
Lung Cancer
November 2024
Department of General Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department for BioMedical Research (DBMR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address:
Pleural mesothelioma (PM) is an aggressive cancer with limited treatment options. In particular, the frequent loss of tumor suppressors, a key oncogenic driver of the disease that is therapeutically intractable, has hampered the development of targeted cancer therapies. Here, we interrogate the PM genome using CRISPR-mediated gene editing to systematically uncover PM cell susceptibilities and provide an evidence-based rationale for targeted cancer drug discovery.
View Article and Find Full Text PDFThe Significance of the Morphological Appearance of Peritoneal Lesions on Imaging in Patients With Peritoneal Malignancies-A Report From Phase 1 of the PRECINCT Study.
J Surg Oncol
September 2024
Department of Surgical Oncology, Centre Hospitalier Lyon-Sud, Lyon, France.
Article Synopsis
- The PRECINCT study evaluated how different morphological appearances of peritoneal malignancies on imaging related to pathological findings in a large patient group.
- It involved the analysis of imaging from 630 patients across seven centers, using 24 morphological terms to describe peritoneal tumors, highlighting high pathological positivity rates for several specific appearances.
- The study recommends standardizing morphological descriptions in radiology reports to improve diagnostic accuracy and proposes that expert radiologists develop a consensus on terminology for better communication in clinical practice.
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