AI Article Synopsis
- The study introduces a method for cross-coupling aryl bromides with nitriles using nickel as a catalyst, triggered by visible light.
- This approach allows for the easy creation of various aryl ketones from common nitriles, highlighting its efficiency and versatility.
- The method operates under mild conditions and can tolerate acidic functional groups, making it a simpler alternative to traditional Grignard or organolithium reactions.
Article Abstract
Herein, a visible-light-induced nickel-catalyzed cross-coupling of aryl bromide with nitrile has been reported. By utilization of readily available nitriles as carbonyl precursors, a range of structurally diverse aryl ketones were facilely constructed. The synthetic simplicity, mild reaction conditions, and acidic functional group tolerance would broaden the synthetic utilities of this developed protocol as an expedient alternative to Grignard/organolithium protocols.
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| http://dx.doi.org/10.1021/acs.orglett.3c03458 | DOI Listing |
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