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Preconceptional and Periconceptional Folic Acid Supplementation in the Visegrad Group Countries for the Prevention of Neural Tube Defects.
Nutrients
December 2024
2nd Department of Gynecology and Obstetrics, University Hospital Bratislava and Comenius University, 821 01 Bratislava, Slovakia.
Neural tube defects (NTDs) are malformations of the central nervous system that represent the second most common cause of congenital morbidity and mortality, following cardiovascular abnormalities. Maternal nutrition, particularly folic acid, a B vitamin, is crucial in the etiology of NTDs. FA plays a key role in DNA methylation, synthesis, and repair, acting as a cofactor in one-carbon transfer reactions essential for neural tube development.
View Article and Find Full Text PDFMethylome profiling of cell-free DNA during the early life course in (un)complicated pregnancies using MeD-seq: Protocol for a cohort study embedded in the prospective Rotterdam periconception cohort.
PLoS One
January 2025
Department of Obstetrics and Gynaecology, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands.
Introduction: Placental DNA methylation differences have been associated with timing in gestation and pregnancy complications. Maternal cell-free DNA (cfDNA) partly originates from the placenta and could enable the minimally invasive study of placental DNA methylation dynamics. We will for the first time longitudinally investigate cfDNA methylation during pregnancy by using Methylated DNA Sequencing (MeD-seq), which is compatible with low cfDNA levels and has an extensive genome-wide coverage.
View Article and Find Full Text PDFMaternal green space exposure and congenital heart defects: A population-based study.
Environ Res
December 2024
Research Center of China Medical University Birth Cohort, Shengjing Hospital of China Medical University, Shenyang, 110004, China; Health Sciences Institute, China Medical University, Shenyang, 110122, China. Electronic address:
Article Synopsis
- The study investigates the relationship between maternal exposure to green spaces and the occurrence of congenital heart defects (CHDs) in newborns, revealing a potential protective effect.
- Analyzed data from over 570,000 births in Liaoning Province, China, showing that increased green space exposure during the periconception period significantly reduces the risk of CHDs by 5%.
- The findings recommend that improving green space coverage, particularly in areas currently lacking it, could decrease the incidence of CHDs and highlights the importance of incorporating green space into public health policies.
Birth prevalence and determinants of neural tube defects among newborns in Ethiopia: A systematic review and meta-analysis.
PLoS One
January 2025
Department of Public Health Sciences, College of Medicine and Health Sciences, Mekelle University, Mekelle, Ethiopia.
Background: Neural tube defects (NTDs) are complex multifactorial disorders in the neurulation of the brain and spinal cord that develop in humans between 21 and 28 days of conception. Neonates with NTDs may experience morbidity and mortality, with severe social and economic consequences. Therefore, the aim of this systematic review and meta-analysis is to assess the pooled prevalence and determinants for neural tube defects among newborns in Ethiopia.
View Article and Find Full Text PDFMaternal pesticide exposure and risk of birth defects: a population-based cross-sectional study in China.
Front Public Health
December 2024
Department of Epidemiology and Health Statistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Objective: This study aimed to examine the association between maternal pesticide exposure during the periconceptional period and birth defects in their offspring.
Methods: A survey was conducted among 29,204 women with infants born between 2010 and 2013 in Shaanxi Province, Northwest China. All cases of birth defects were diagnosed using the International Classification of Diseases, Tenth Revision (ICD-10).
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