In this paper, a new off-policy two-dimensional (2D) reinforcement learning approach is proposed to deal with the optimal tracking control (OTC) issue of batch processes with network-induced dropout and disturbances. A dropout 2D augmented Smith predictor is first devised to estimate the present extended state utilizing past data of time and batch orientations. The dropout 2D value function and Q-function are further defined, and their relation is analyzed to meet the optimal performance. On this basis, the dropout 2D Bellman equation is derived according to the principle of the Q-function. For the sake of addressing the dropout 2D OTC problem of batch processes, two algorithms, i.e., the off-line 2D policy iteration algorithm and the off-policy 2D Q-learning algorithm, are presented. The latter method is developed by applying only the input and the estimated state, not the underlying information of the system. Meanwhile, the analysis with regard to the unbiasedness of solutions and convergence is separately given. The effectiveness of the provided methodologies is eventually validated through the application of a simulated case during the filling process.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.isatra.2023.11.011 | DOI Listing |
Appl Biochem Biotechnol
January 2025
Department of Biotechnology-CBS, Metropolitan Autonomous University Iztapalapa, Av. Ferrocarril San Rafael Atlixco 186, 09310, Mexico City, Mexico.
The presence of antibiotics in wastewater discharges significantly affects the environment, mainly due to the generation of bacterial populations with multiple antibiotic resistances. The cometabolic capacity of nitrifying sludge to simultaneously remove ammonium (NH) and emerging organic contaminants (EOCs), including antibiotics, has been reported. In the present study, the removal capacity of 50 mg ampicillin (AMP)/L by nitrifying cultures associated with biosorption and biotransformation processes was evaluated in a sequencing batch reactor (SBR) system.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Marina del Rey, CA, USA.
Background: Amyloid-β (Aβ) plaques and tau pathogenesis in the brain precede cognitive decline in the progression of Alzheimer's dementia, yet the extent to which these measures can predict localized brain tissue atrophy has not been studied in a large, diverse population. Multisite studies offer robust statistical power with larger sample sizes but are confounded by variations in biomarker quantification across studies, including variations in MRI scanners, PET tracers, and CSF assays. Longitudinal data from N=1223 individuals from four independent AD studies were harmonized to assess localized brain tissue atrophy over 2 to 5 years.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Mallinckrodt Institute of Radiology, Washington University School of Medicine in St Louis, St Louis, MO, USA.
Background: Differences in amyloid PET radiotracer pharmacokinetics and binding properties lead to discrepancies in amyloid uptake measurements, which may adversely affect the statistical power of clinical trials that utilize multiple tracers to track brain amyloid deposition. To address this, Centiloid was developed for standardizing global amyloid SUVRs across tracers to a common scale. Alternatively, ComBat is a technique for harmonizing batch effects while preserving variations from biologically-relevant covariates.
View Article and Find Full Text PDFBackground: Cerebrospinal fluid (CSF) is an important source of protein biomarkers for diagnosis, risk stratification, and predicting treatment response in Alzheimer's disease (AD). Proximity to brain parenchyma suggests that CSF proteomic alterations may mirror brain pathological changes. Understanding the evolution of CSF proteomic changes and their alignment with concurrent brain pathology necessitates matched CSF and brain analyses, which are possible using animal models of AD pathology.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Translational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montréal, QC, Canada.
Background: Timely and non-invasive prediction of amyloid status are pivotal in Alzheimer's disease (AD) diagnostics. This research leverages T1 MRI images to predict amyloid positivity or negativity, offering an economical and less invasive alternative to amyloid PET scans. Using the comprehensive TRAID dataset from McGill University, the study evaluates a spectrum of cognitive conditions including AD, atypical AD, Cognitively Normal (CN), Mild Cognitive Impairment (MCI), MCI not due to AD, Suspected Non-Alzheimer's Pathophysiology (SNAP), and Vascular MCI (VMCI).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!