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Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies.
Lancet
January 2025
Department of Medicine I, Agaplesion Markus Hospital, Goethe University, Frankfurt, Germany.
Background: Interleukin-23 inhibition is effective in treating ulcerative colitis. Guselkumab is a dual-acting, human IgG1, interleukin-23p19 subunit inhibitor that potently neutralises interleukin-23 and can bind to CD64. We aimed to evaluate the efficacy and safety of guselkumab as induction and maintenance therapy in patients with ulcerative colitis.
View Article and Find Full Text PDFImpact of drying techniques on volatile aroma profiles and formation mechanisms of black soybean thua nao.
Food Chem X
December 2024
Department of Food Technology, Faculty of Science, Chulalongkorn University, Phayatai Road, Wangmai, Pathumwan, Bangkok 10330, Thailand.
Thua nao, a traditional Thai fermented soybean, offers a unique aroma and nutritional value. However, fresh thua nao cannot be stored for long periods due to its high in water activity (a). This study examined the effects of various drying methods, including natural sun drying and machine drying methods, namely hot air, microwave vacuum (MIC), and vacuum drying on the qualities of dried black soybean thua nao.
View Article and Find Full Text PDFMapping the relationship between alcohol use disorder and gut microbiota: a 20-year bibliometric study.
Front Microbiol
November 2024
Department of Psychiatry, The School of Clinical Medicine, Hunan University of Chinese Medicine, Changsha, China.
Background: Alcohol use disorder (AUD) is a psychiatric disorder that is widespread worldwide. Alcohol use is a significant contributor to the global burden of death, disability and disease. Modulation of the gut microbiota is a promising approach to improve the efficacy and minimize the adverse effects of colorectal cancer treatment.
View Article and Find Full Text PDFPopulation genomics of a thermophilic cyanobacterium revealed divergence at subspecies level and possible adaptation genes.
Bot Stud
November 2024
Institute of Plant and Microbial Biology, Academia Sinica, Taipei, 115201, Taiwan.
Article Synopsis
- Cyanobacteria, specifically Thermosynechococcus taiwanensis, are being studied for their ecological role and biotechnological potential, including bioethanol production and pollutant degradation.
- Researchers isolated 27 novel strains from hot springs in Taiwan and performed genomic analyses on 32 strains, revealing a total of around 3,030 genes in their pan-genome and significant genetic diversity.
- The study identified that within two major populations of this species, selective sweeps targeted different genes related to key functions such as photosynthesis and motility, although the reasons for population divergence remain unclear.
Increased Emergency Department Medical Imaging: Association with Short-Term Exposures to Ambient Heat and Particulate Air Pollution.
Radiology
November 2024
From the Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada (K.H., A. Kirpalani, B.E.W., J.A., H.S., A. Kielar, M.P.); Joint Department of Medical Imaging, University Medical Imaging Toronto, Toronto General Hospital, University Health Network and Sinai Health System, 585 University Ave, 1 PMB-298, Toronto, ON, Canada M5G 2N2 (K.H., H.P., H.S., A. Kielar, M.P.); Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada (O.T.); Department of Medical Imaging, St Michael's Hospital, Toronto, Ontario, Canada (A. Kirpalani); Department of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, Ontario, Canada (B.E.W., J.A.); Departments of Environmental Health (S.D.) and Biostatistics (R.C.N.), Harvard T. H. Chan School of Public Health, Boston, Mass; Department of Emergency Medicine, University Health Network, Toronto, Ontario, Canada (J.C.); and Department of Radiology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada (M.J.B.).
Background Climate change adversely affects human health, resulting in higher demand for health care services. However, the impact of climate-related environmental exposures on medical imaging utilization is currently unknown. Purpose To determine associations of short-term exposures to ambient heat and particulate air pollution with utilization of emergency department medical imaging.
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