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| http://dx.doi.org/10.3389/fmicb.2023.1321166 | DOI Listing |
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Nonhuman primate models of pediatric viral diseases.
Front Cell Infect Microbiol
December 2024
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, United States.
Infectious diseases are the leading cause of death in infants and children under 5 years of age. exposure to viruses can lead to spontaneous abortion, preterm birth, congenital abnormalities or other developmental defects, often resulting in lifelong health sequalae. The underlying biological mechanisms are difficult to study in humans due to ethical concerns and limited sample access.
View Article and Find Full Text PDFOropouche virus: Understanding "sloth fever" disease dynamics and novel intervention strategies against this emerging neglected tropical disease.
Virulence
December 2024
Department of Veterinary & Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, MN, USA.
Article Synopsis
- Oropouche virus (OROV) is an arbovirus that causes "sloth fever," transmitted mainly by midges in both rural and urban areas.
- Human infections can result in acute fever and, in severe cases, neurological issues, with over half a million people infected since its first detection in 1955.
- The absence of FDA-approved vaccines and treatments means current care focuses on supportive measures, highlighting the importance of developing vaccines to control outbreaks, especially as OROV risk increases with climate change and global travel.
Sustained antiviral insulin signaling during West Nile virus infection results in viral mutations.
Front Cell Infect Microbiol
December 2024
School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, United States.
Arthropod-borne viruses or arboviruses, including West Nile virus (WNV), dengue virus (DENV), and Zika virus (ZIKV) pose significant threats to public health. It is imperative to develop novel methods to control these mosquito-borne viral infections. We previously showed that insulin/insulin-like growth factor-1 signaling (IIS)-dependent activation of ERK and JAK-STAT signaling has significant antiviral activity in insects and human cells.
View Article and Find Full Text PDFBioluminescent and fluorescent reporter-expressing recombinant Akabane virus (AKAV): an excellent tool to dissect viral replication.
Front Microbiol
November 2024
State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Article Synopsis
- The Akabane virus (AKAV) is an arbovirus that mainly affects livestock and causes severe congenital abnormalities.
- Researchers developed a reverse genetics system for AKAV, creating recombinant viruses (rAKAV-Nluc and rAKAV-mWasabi) that produce luminescent indicators for studying the virus.
- The study showed that these recombinant viruses maintain similar growth characteristics to the original virus, allowing for further investigation into AKAV's virulence and the range of cell types it can infect.*
Analysis of the interrelationship between precipitation and confirmed dengue cases in the city of Recife (Brazil) covering climate and public health information.
Front Public Health
November 2024
Department of Atmospheric Sciences, Institute of Astronomy, Geophysics and Atmospheric Sciences (IAG), University of São Paulo, São Paulo, Brazil.
Article Synopsis
- Large-scale epidemics of arboviruses like dengue emphasize the importance of understanding the environmental factors that affect vector populations, particularly in urban areas.
- A study conducted in Recife, Brazil, found a correlation between rainfall and confirmed dengue cases, with higher incidences during the rainy season, though surprising outbreaks occurred during drier months.
- The research highlights the complexity of dengue dynamics, indicating that while precipitation is important, other factors such as serotype circulation and broader climate influences also play crucial roles in disease spread.
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