Background: Diminishing hormonal levels after menopause evoke physiological changes in a woman's body. Their effects on the oral cavity are noteworthy, considering symptoms of dry mouth, altered taste perceptions, and tooth loss that may be attributed to reduced salivary flow and alveolar density changes.
Aim: The purpose of this study was to assess changes in salivary flow rate, tooth loss, and oral health-related quality of life (OHRQoL) as menopausal duration increased.
Materials And Methods: A total of 327 women fulfilling the eligibility criteria were chosen from two villages in the Mysuru district, Karnataka. They were categorized into three groups based on menopausal durations. Salivary flow rates, number of teeth lost, and OHRQoL after menopause were assessed and compared at different menopausal durations. Sociodemographic characteristics and oral hygiene practices were recorded to identify potential confounders.
Results: Multivariate analysis demonstrated a significant association between menopausal duration and salivary flow rates (adjusted odds ratio = 2.269). However, no such associations were observed with tooth loss and OHRQoL.
Conclusion: Menopausal duration significantly affects salivary flow rate. Its influence on tooth loss and OHRQoL is, however, less evident. Although strong associations cannot be established, the inevitability of the menopausal state advocates consideration of other major yet modifiable factors to improve oral health.
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http://dx.doi.org/10.4103/jmh.jmh_41_22 | DOI Listing |
Sci China Life Sci
December 2024
State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
Salivary proteins serve multifaceted roles in maintaining oral health and hold significant potential for diagnosing and monitoring diseases due to the non-invasive nature of saliva sampling. However, the clinical utility of current saliva biomarker studies is limited by the lack of reference intervals (RIs) to correctly interpret the testing result. Here, we developed a rapid and robust saliva proteome profiling workflow, obtaining coverage of >1,200 proteins from a 50-µL unstimulated salivary flow with 30 min gradients.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
December 2024
Innovation Center in Salivary Diagnostics and Nanobiotechnology, Department of Physiology, Institute of Biomedical Sciences, Federal University of Uberlandia (UFU), Uberlandia, MG, Brazil. Electronic address:
The non-invasive detection of crack/cocaine and other bioactive compounds from its pyrolysis in saliva can provide an alternative for drug analysis in forensic toxicology. Therefore, a highly sensitive, fast, reagent-free, and sustainable approach with a non-invasive specimen is relevant in public health. In this animal model study, we evaluated the effects of exposure to smoke crack cocaine on salivary flow, salivary gland weight, and salivary composition using Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy.
View Article and Find Full Text PDFImmun Inflamm Dis
December 2024
Department of Endodontics, School of Dentistry, Islamic Azad University, Tehran, Iran.
Introduction: Oral lichen planus (OLP) is a chronic disorder affecting the oral mucosa, potentially associated with xerostomia, either independently or concurrently. Research suggests that approximately 45% of patients with erythematous and ulcerative OLP may experience dry mouth sensations. The aim of this systematic review is to assess the current literature regarding the potential relationship or co-occurrence of xerostomia with OLP.
View Article and Find Full Text PDFJPRAS Open
March 2025
Department of Plastic and Reconstructive Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-ku, Sapporo City, Hokkaido 060-8638, Japan.
Esophagojejunal anastomotic fistula is difficult to treat because of continuous salivary flow. This report describes the innovative use of a negative pressure wound therapy device with a slit drain to treat an esophagojejunal anastomotic fistula after free jejunal transfer. Insertion of a slit drain was very effective for management of saliva.
View Article and Find Full Text PDFCancer Med
December 2024
Department of Radiotherapy, Centre Eugène Marquis, Rennes, France.
Background: Modern imaging techniques with magnetic resonance imaging (MRI) or positron emission tomography/computed tomography (PET/CT) have recently been developed to assess radiation-induced damage to salivary structures. The primary aim of this review was to summarize evidence on the imaging modalities used for the assessment and prediction of xerostomia after head and neck radiotherapy (RT).
Methods: A systematic review of the literature was performed using successively the MeSH terms "PET," "MRI," "scintigraphy," "xerostomia," and "radiotherapy.
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