expression-based prognostic model for uveal melanoma.

FOXD1, a new member of the transcription factor family, serves as a mediator and biomarker for cell reprogramming. But its contribution to prognosis of uveal melanoma (UVM) is unclear. This study demonstrated that might promote tumor growth and invasion, because expression was negatively correlated with overall survival, progression-free survival, and disease-specific survival in UVM patients. This conjecture was verified in cell culture with human uveal melanoma cell line (MUM2B) as model cells. Additionally, the biological mechanisms of based on -related genomic spectrum, molecular pathways, tumor microenvironment, and drug treatment sensitivity were examined using The Cancer Genome Atlas (TCGA) database, aiming to reasonably explain why leads to poor prognosis of UVM. On these bases, a novel tumor prognostic model was established using the -related immunomodulators , , , and , which will enable the stratification of disease seriousness and clinical treatment for patients.