AI Article Synopsis
- MTF-1, a metal-responsive transcription factor, plays a crucial role in cancer progression, but its relationship with immune infiltration in low-grade gliomas (LGG) is not well understood.
- Using data from The Cancer Genome Atlas, researchers analyzed MTF-1 levels in LGG and healthy brain tissues, confirming findings through immunohistochemistry and exploring MTF-1's impact on patient prognosis and tumor biology.
- Results indicated that MTF-1 overexpression is associated with poorer overall survival and lower immune cell infiltration, suggesting it could serve as a novel prognostic biomarker for LGG.
Article Abstract
Background: Metal-responsive transcription factor-1 performs a necessary position in a range of cancers. It is unknown, though, how the prognosis of patients with low-grade gliomas is related to immune infiltration.
Method: The Cancer Genome Atlas database was used in this investigation to evaluate MTF-1 transcription in low-grade glioma and healthy brain tissues, and immunohistochemistry was used to confirm MTF-1 levels. By using functional enrichment analysis and R software, the putative biological roles and signaling pathways connected to MTF-1 in LGG as well as its prognostic significance were investigated. Further research was done on the connection involving MTF-1 and tumor mutational burden in LGG. Finally, the research evaluated how MTF-1 and immune cell infiltration are related.
Results: We noticed that the WHO grade, 1p/19q codeletion, and older age were all substantially linked with MTF-1 overexpression in low-grade gliomas. OS and disease-specific survival were significantly lowered as a result of MTF-1 transcription. MTF-1 was recognized as an independent OS prognostic predictor with a poor prognosis by multifactorial Cox analysis. Functional enrichment analysis revealed that the primary enrichment pathways were chemical carcinogenesis-receptor activation and the generation of miRNAs implicated in gene suppression by miRNA. Additionally, there was a negative correlation between MTF-1 overexpression and the degree of immune cell infiltration in neutrophils and DC.
Conclusion: MTF-1 may be a novel prognostic biomarker.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643104 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2023.e21159 | DOI Listing |
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