AI Article Synopsis
- Cancer cells have altered mechanosensing abilities due to changes in specific cytoskeletal proteins, affecting their interaction with the tumor microenvironment (TME).
- This altered mechanosensing contributes to the development and progression of cancer by changing how cells respond to mechanical forces.
- Recent advances in understanding cell biomechanics have led to new strategies aimed at targeting these mechanobiological properties to inhibit cancer growth and its spread.
Article Abstract
Cancer cells exhibit aberrant extracellular matrix mechanosensing due to the altered expression of mechanosensory cytoskeletal proteins. Such aberrant mechanosensing of the tumor microenvironment (TME) by cancer cells is associated with disease development and progression. In addition, recent studies show that such mechanosensing changes the mechanobiological properties of cells, and in turn cells become susceptible to mechanical perturbations. Due to an increasing understanding of cell biomechanics and cellular machinery, several approaches have emerged to target the mechanobiological properties of cancer cells and cancer-associated cells to inhibit cancer growth and progression. In this Perspective, we summarize the progress in developing mechano-based approaches to target cancer by interfering with the cellular mechanosensing machinery and overall TME.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10652740 | PMC |
| http://dx.doi.org/10.1021/acsomega.3c06451 | DOI Listing |
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