tandem duplications are recurrent in adult and paediatric acute myeloid leukaemia and have been reported to be associated with a poor prognosis. Co-mutations in and are common while morphological dysplasia is frequent. The role of UBTF-TDs in leukemogenesis is yet to be elucidated; however they have been proposed as early initiating events, making them attractive for assessment of MRD and a potential therapeutic target. We present two cases where the TD was observed in remission and discuss the implications of these findings in the clinicobiological understanding of this emerging entity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10660390 | PMC |
| http://dx.doi.org/10.1002/jha2.808 | DOI Listing |
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