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| http://dx.doi.org/10.1002/trc2.12435 | DOI Listing |
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Schistosomiasis treatment in young children: a welcome step towards deployment of the paediatric praziquantel formulation.
Int Health
January 2025
Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
It is an awkward fact that effective public health control of schistosomiasis in Africa has yet to deliver a fully comprehensive intervention for appropriate anthelmintic treatment of those preschool-age children and infants with active infection(s) and/or insidious disease. Over the last decade, despite the steady progress of the Pediatric Praziquantel Consortium in developing a monoenantiomeric oral dispersible tablet, future challenges remain in securing its deployment and implementation at scale. This commentary provides a forward-looking critique for the international community, reminding us of this unfortunate treatment gap, and seeks to encourage commensurate action on ameliorating this overlooked medical inequity.
View Article and Find Full Text PDFMTIOT: Identifying HPV subtypes from multiple infection data.
Comput Struct Biotechnol J
December 2024
Key Laboratory of Systems Biology, Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China.
Persistent infection with high-risk human papillomavirus (hrHPV) is a major cause of cervical cancer. The effectiveness of current HPV-DNA testing, which is crucial for early detection, is limited in several aspects, including low sensitivity, accuracy issues, and the inability to perform comprehensive hrHPV typing. To address these limitations, we introduce MTIOT (Multiple subTypes In One Time), a novel detection method that utilizes machine learning with a new multichannel integration scheme to enhance HPV-DNA analysis.
View Article and Find Full Text PDFHealth simulation masterclass in Morocco: First edition of training of trainers.
J Educ Health Promot
December 2024
Faculty of Medicine and Pharmacy, University Mohammed V in Rabat, Morocco.
Background: The confluence of recent events has led to a notable increase in the use of health simulation. This work aimed to present and describe the first masterclass program in healthcare simulation dedicated to trainers at Rabat's Faculty of Medicine and Pharmacy with the close collaboration of Mohammad VI Foundation of Health and Sciences for its first edition in Morocco.
Materials And Methods: This was an observational study.
New Data on Ulipristal Acetate and Misoprostol for Medication Abortion - A Step Forward?
NEJM Evid
January 2025
Advancing New Standards in Reproductive Health (ANSIRH), Bixby Center for Global Reproductive Health, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco (UCSF).
Identification of three distinct cell populations for urate excretion in human kidneys.
J Physiol Sci
January 2025
Department of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan; V-iCliniX Laboratory, Nara Medical University, Kashihara, Nara, Japan. Electronic address:
In humans, uric acid is an end-product of purine metabolism. Urate excretion from the human kidney is tightly regulated by reabsorption and secretion. At least eleven genes have been identified as human renal urate transporters.
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