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Impact of In-house Polymerase Chain Reaction Screening on Admission on the Incidence Rates of Surveillance and Blood Cultures With and Associated Cost Savings. | LitMetric

AI Article Synopsis

Article Abstract

Background: The impact of strategies for rapid diagnostic screening of on hospital operations has not been previously characterized. We describe the implementation of in-house polymerase chain reaction (PCR) testing on admission for screening of colonization with associated process improvements, and financial impact.

Methods: This study was conducted across an integrated health system. Patients were tested based on risk factors for carriage. Pre-intervention, the PCR was sent out to a reference laboratory, and postintervention was performed in-house. Changes in the incidence rates (IRs) of present on admission (CA-POA) and hospital-onset fungemia (CA-HOF) were assessed using interrupted time series analysis. The economic impact on isolation and testing costs was calculated.

Results: Postintervention, the IR of CA-POA doubled (IRR, 2.57; 95% CI, 1.16-5.69; = .02) compared with the pre-intervention period. The baseline rate of CA-HOF was increasing monthly by 14% (95% CI, 1.05-1.24; = .002) pre-intervention, while during the postintervention period there was a change in slope with a monthly decrease in IR of 13% (95% CI, 0.80-0.99; = .02). The median turnaround time (TAT) of the results (interquartile range) was reduced from 11 (8-14) days to 2 (1-3) days. Savings were estimated to be between $772 513.10 and $3 730 480.26.

Conclusions: By performing in-house PCR for screening of colonization on admission, we found a doubling of CA-POA rates, a subsequent decrease in CA-HOF rates, reduced TAT for PCR results, and more efficient use of infection control measures. In-house testing was cost-effective in a setting of relatively high prevalence among individuals with known risk factors.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665036PMC
http://dx.doi.org/10.1093/ofid/ofad567DOI Listing

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