AI Article Synopsis
- Turner syndrome is linked to a higher risk of various tumors, especially thyroid cancers due to chronic thyroiditis.
- A rare case of solid variant papillary thyroid carcinoma was found in a 22-year-old woman with Turner syndrome during chronic thyroiditis follow-up, with no history of radiation exposure.
- Genetic tests showed no known mutations related to this cancer type, suggesting that the development of this variant might follow different mechanisms in Turner syndrome patients than previously understood.
Article Abstract
Turner syndrome is associated with an increased risk of developing several neoplasms. In particular, a clinical feature of Turner syndrome with chronic thyroiditis implies a relationship with thyroid malignancies. We report a very rare case of a solid variant of papillary thyroid carcinoma that was identified during a follow-up of chronic thyroiditis in a 22-year-old woman with Turner syndrome. The patient had no notable history of radiation exposure. No genetic mutations relating to the occurrence of the solid variant of papillary thyroid carcinoma, including /PTC rearrangements and mutations in the or , were detected by a gene panel test, namely, the Oncomine™ Dx Target test. To the best of our knowledge, this is the first report of a solid variant of papillary thyroid carcinoma in a young adult with Turner syndrome with chronic thyroiditis. Our case suggests that in patients with Turner syndrome, there may be different pathogeneses from those previously reported, including exposure to radiation or known genetic mutations for the development of a solid variant of papillary thyroid carcinoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665479 | PMC |
| http://dx.doi.org/10.3389/fonc.2023.1150002 | DOI Listing |
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