Investigation of the Methodology of Specific Airway Resistance Measurements in COPD.

Int J Chron Obstruct Pulmon Dis

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester University NHS Foundation Trust, Manchester, UK.

Published: December 2023

Introduction: Specific resistance (SR) measurements in Chronic Obstructive Pulmonary Disease (COPD) patients may be performed by panting or tidal breathing. The aim of this study was to compare how breathing frequency affected SR in COPD and compare different tangent plotting methods.

Methods: Fifteen COPD patients participated. Three protocols were performed: tidal 1 - spontaneous tidal breathing; tidal 2 - tidal breathing with a flow of ±1 L/sec; panting - 60 breaths per min. Effective (SR), total (SR), ±0.5 L/s (SR), and mid (SR) specific resistance were assessed.

Results: The tidal breathing protocols provided similar results. Panting resulted in higher SR (p = 0.0002) and SR (p < 0.0001) versus tidal breathing, but not SR or SR. Breathing frequency did not affect intra-test variance. SR and SR measurements were similar, and were higher than SR, during tidal breathing (p = 0.0014 and p < 0.0001 respectively) and panting (p = 0.0179 and p < 0.0001 respectively). SR was higher than SR during tidal breathing (p < 0.0001) and panting (p < 0.0001). Intra-test variance of SR and SR were similar and showed the lowest percent coefficient of variation during both tidal breathing and panting.

Conclusion: Panting and tidal breathing manoeuvres are not interchangeable in COPD patients. Panting widens the clubbing in the SR loop. SR and SR may underestimate abnormal physiology in COPD.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655747PMC
http://dx.doi.org/10.2147/COPD.S424696DOI Listing

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