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| http://dx.doi.org/10.3389/fimmu.2023.1327091 | DOI Listing |
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HSF1 at the crossroads of chemoresistance: from current insights to future horizons in cell death mechanisms.
Front Cell Dev Biol
January 2025
Department of Cell and Cancer Biology, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, United States.
Heat Shock Factor 1 (HSF1) is a major transcriptional factor regulating the heat shock response and has become a potential target for overcoming cancer chemoresistance. This review comprehensively examines HSF1's role in chemoresistance and its potential as a therapeutic target in cancer. We explore the complex, intricate mechanism that regulates the activation of HSF1, HSF1's function in promoting resistance to chemotherapy, and the strategies used to manipulate HSF1 for therapeutic benefit.
View Article and Find Full Text PDFIntroduction: Tuberculosis (TB) poses a significant threat to global health, with millions of new infections and approximately one million deaths annually. Various modeling efforts have emerged, offering tailored data-driven and physiologically-based solutions for novel and historical compounds. However, this diverse modeling panorama may lack consistency, limiting result comparability.
View Article and Find Full Text PDFFostering effective hybrid human-LLM reasoning and decision making.
Front Artif Intell
January 2025
Center for Mind/Brain Sciences, University of Trento, Trento, Italy.
The impressive performance of modern Large Language Models (LLMs) across a wide range of tasks, along with their often non-trivial errors, has garnered unprecedented attention regarding the potential of AI and its impact on everyday life. While considerable effort has been and continues to be dedicated to overcoming the limitations of current models, the potentials and risks of human-LLM collaboration remain largely underexplored. In this perspective, we argue that enhancing the focus on human-LLM interaction should be a primary target for future LLM research.
View Article and Find Full Text PDFObjectives: To evaluate the impact of hospitalisation for infectious diseases on the Health-Related Quality of life (HRQOL), multidimensional frailty, and functioning of older patients, we conducted a longitudinal matched cohort study in four European countries.
Methods: HRQOL, frailty, and functioning were assessed using validated questionnaires at inclusion, at discharge, and up to six months later (M6) in patients aged over 65 years hospitalised for severe acute respiratory or bloodstream infections, and matched controls hospitalised for non-infectious conditions. Comparative analyses employed multilevel mixed-effect linear or logistic models to assess changes from inclusion.
The publication fate of abstracts awarded prizes at European Society of Paediatric Radiology annual scientific meetings.
Pediatr Radiol
January 2025
School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Background: The European Society of Paediatric Radiology (ESPR) awards prizes for outstanding work presented at their annual scientific meetings. The proportion of ESPR prize-winning abstracts to journal publications is not known. Contextualising abstract-to-publication proportions by evaluating publication experience can yield valuable insights and actionable outcomes to support researchers in overcoming barriers to journal publication.
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